Large-scale genome sequencing is providing a comprehensive view of the complex
evolutionary forces that have shaped the structure of eukaryotic chromosomes. Comparative …

This study examines genomic duplications, deletions, and rearrangements that have
happened at scales ranging from a single base to complete chromosomes by comparing the …

We aligned and analyzed 100 pairs of complete, orthologous intergenic regions from the
human and mouse genomes (average length∼ 12 000 nucleotides). The alignments …

Knowledge of the rate of point mutation is of fundamental importance, because mutations
are a vital source of genetic novelty and a significant cause of human diseases. Currently …

Although analysis of genome rearrangements was pioneered by Dobzhansky and
Sturtevant 65 years ago, we still know very little about the rearrangement events that …

A common assumption in comparative sequence analysis is that the sequences have
evolved with the same pattern of nucleotide substitution (homogeneity of the evolutionary …

Comparing chromosomal gene order in two or more related species is an important
approach to studying the forces that guide genome organization and evolution. Linked …

The nuclear ribosomal DNA (nuc-rDNA) is widely used for the identification and
phylogenetic reconstruction of Agaricomycetes. However, nuc-rDNA-based phylogenies …

The identification of homologous regions between chromosomes forms the basis for studies
of genome organization, comparative genomics, and evolutionary genomics. Identification of …

Background Vertebrate genes often appear to cluster within the background of
nontranscribed genomic DNA. Here an analysis of the physical distribution of gene …