The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …

Phosphoinositide signaling lipids are crucial for eukaryotes and regulate many aspects of
cell function. These signaling molecules are difficult to study because they are extremely low …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from
many diverse genetic causes. Although therapeutics specifically targeting known causal …

Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …

In Alzheimer's disease (AD), β‐amyloid peptides aggregate to form amyloid plaques, and
the microtubule‐associated protein tau forms neurofibrillary tangles. However, severity and …

Endocytosis, required for the uptake of receptors and their ligands, can also introduce
pathological aggregates such as α-synuclein (α-syn) in Parkinson's Disease. We show here …

Brain-matter vacuolation is a defining trait of all prion diseases, yet its cause is unknown.
Here, we report that prion infection and prion-mimetic antibodies deplete the …

An emerging theme in Parkinson's disease (PD) is the propagation of α-synuclein pathology
as the disease progresses. Research involving the injection of preformed α-synuclein fibrils …

Neurodegenerative diseases are hitherto classified based on their core clinical features, the
anatomical distribution of neurodegeneration, and the cell populations mainly affected. On …