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WWOX phosphorylation, signaling, and role in neurodegeneration
CC Liu, PC Ho, IT Lee, YA Chen, CH Chu… - Frontiers in …, 2018 - frontiersin.org
Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural
diseases, metabolic disorders and early death in the newborns of humans, mice and rats …
diseases, metabolic disorders and early death in the newborns of humans, mice and rats …
WW domain-containing oxidoreductase in neuronal injury and neurological diseases
HT Chang, CC Liu, ST Chen, YV Yap, NS Chang… - …, 2014 - pmc.ncbi.nlm.nih.gov
The human and mouse WWOX/Wwox gene encodes a candidate tumor suppressor WW
domain-containing oxidoreductase protein. This gene is located on a common fragile site …
domain-containing oxidoreductase protein. This gene is located on a common fragile site …
The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration
G Abdel-Salam, M Thoenes, HH Afifi, F Körber… - Orphanet journal of rare …, 2014 - Springer
Background WWOX, encoding WW domain-containing oxidoreductase, spans FRA16D, the
second most common chromosomal fragile site frequently altered in cancers. It is therefore …
second most common chromosomal fragile site frequently altered in cancers. It is therefore …
[HTML][HTML] WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human …
WWOX gene loss-of-function (LoF) has been associated with neuropathologies resulting in
developmental, epileptic, and ataxic phenotypes of varying severity based on the level of …
developmental, epileptic, and ataxic phenotypes of varying severity based on the level of …
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation
The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is
frequently lost in many cancer types. Wwox-deficient mice develop normally but succumb to …
frequently lost in many cancer types. Wwox-deficient mice develop normally but succumb to …
[HTML][HTML] Pleiotropic functions of tumor suppressor WWOX in normal and cancer cells
M Abu-Remaileh, E Joy-Dodson… - Journal of Biological …, 2015 - Elsevier
WW domain-containing oxidoreductase (WWOX), originally marked as a likely tumor
suppressor gene, has over the years become recognized for its role in a much wider range …
suppressor gene, has over the years become recognized for its role in a much wider range …
[HTML][HTML] The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders
I Baryła, E Styczeń-Binkowska, E Płuciennik… - International Journal of …, 2022 - mdpi.com
Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play
an initiating role in glucotoxicity, which underlies disorders in metabolic diseases. WWOX …
an initiating role in glucotoxicity, which underlies disorders in metabolic diseases. WWOX …
[HTML][HTML] WWOX somatic ablation in skeletal muscles alters glucose metabolism
Objective WWOX, a well-established tumor suppressor, is frequently lost in cancer and plays
important roles in DNA damage response and cellular metabolism. Methods We re-analyzed …
important roles in DNA damage response and cellular metabolism. Methods We re-analyzed …
The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability
The fragile WWOX gene, encompassing the chromosomal fragile site FRA16D, is frequently
altered in human cancers. While vulnerable to DNA damage itself, recent evidence has …
altered in human cancers. While vulnerable to DNA damage itself, recent evidence has …
The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism
The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is
frequently altered in cancer. WWOX binds several proteins and thus is postulated to be …
frequently altered in cancer. WWOX binds several proteins and thus is postulated to be …