The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …

The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion
channels. It is vital for neuromuscular transmission and an important regulator of …

The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …

Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …

Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic
potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided …

The vast diversity of neuronal nicotinic acetylcholine subunits expressed in the central and
peripheral nervous systems, as well as in non-neuronal tissues, constitutes a formidable …

Considerable progress has been made in recent years towards the identification and
characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors …

The purpose of our review is to briefly show what different compounds of marine origin, from
low molecular weight ones to peptides and proteins, offer for understanding the structure …