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The stiffness of living tissues and its implications for tissue engineering
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …
Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair
The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …
inflammation following insult or damage to organs. The heart is a vital organ which supplies …
Cardiac fibrosis: the fibroblast awakens
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
Aims Acute myocardial infarction (MI) is the leading cause of mortality worldwide. Anti-
inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to …
inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to …
A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular …
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial
signaling were shown to be specifically altered in heart failure with preserved ejection …
signaling were shown to be specifically altered in heart failure with preserved ejection …
The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …
Titin (TTN): from molecule to modifications, mechanics, and medical significance
CM Loescher, AJ Hobbach… - Cardiovascular research, 2022 - academic.oup.com
The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …
Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering
Cardiac cell therapy holds a real promise for improving heart function and especially of the
chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better …
chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better …
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …
(HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF …
A tissue-engineered scale model of the heart ventricle
Laboratory studies of the heart use cell and tissue cultures to dissect heart function yet rely
on animal models to measure pressure and volume dynamics. Here, we report tissue …
on animal models to measure pressure and volume dynamics. Here, we report tissue …