Bile acid metabolism and signaling, the microbiota, and metabolic disease
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …
gastrointestinal tract contributes to host health through its role in producing energy or …
[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended-spectrum β-lactamase …
Background Antimicrobials are often used to prevent and treat diarrhea induced by
enteroaggregative Escherichia coli (EAEC) in young ruminants. However, drug overuse or …
enteroaggregative Escherichia coli (EAEC) in young ruminants. However, drug overuse or …
Recipient factors in faecal microbiota transplantation: one stool does not fit all
Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases
associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile …
associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile …
Capturing the environment of the Clostridioides difficile infection cycle
Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …
economic burden worldwide. Great strides have been made over the past several years in …
The pathophysiology of farnesoid X receptor (FXR) in the GI tract: inflammation, barrier function and innate immunity
KM Anderson, CP Gayer - Cells, 2021 - mdpi.com
The Farnesoid-X Receptor, FXR, is a nuclear bile acid receptor. Its originally described
function is in bile acid synthesis and regulation within the liver. More recently, however, FXR …
function is in bile acid synthesis and regulation within the liver. More recently, however, FXR …
Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics
Clostridioides difficile is a major nosocomial pathogen, causing significant morbidity and
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …
Targeting gut microbial bile salt hydrolase (BSH) by diet supplements: new insights into dietary modulation of human health
Y Yang, C Wu - Food & Function, 2022 - pubs.rsc.org
The gut microbiome is increasingly recognized as a vital organ that participates in nutrient
acquisition, energy regulation and maintenance of human health. Targeted manipulation of …
acquisition, energy regulation and maintenance of human health. Targeted manipulation of …
Gut associated metabolites and their roles in Clostridioides difficile pathogenesis
The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut
microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well …
microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well …
Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut …
Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides
difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at …
difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at …