As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

Although mutations leading to a compromised nuclear envelope cause diseases such as
muscular dystrophies or accelerated aging, the consequences of mechanically induced …

Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

During aging, deterioration in cardiac structure and function leads to increased susceptibility
to heart failure. The need for interventions to combat this age-related cardiac decline is …

Cells are subjected to endogenous [eg, reactive oxygen species (ROS), replication stress]
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …

Cancer metastasis, ie, the spreading of tumor cells from the primary tumor to distant organs,
is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …