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Tryptophan metabolism in health and disease
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …
[HTML][HTML] Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis
The serotonergic system forms a diffuse network within the central nervous system and plays
a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels …
a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels …
Kynurenine pathway metabolism and the microbiota-gut-brain axis
It has become increasingly clear that the gut microbiota influences not only gastrointestinal
physiology but also central nervous system (CNS) function by modulating signalling …
physiology but also central nervous system (CNS) function by modulating signalling …
Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects
Background Preclinical studies have identified certain probiotics as psychobiotics–live
microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has …
microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has …
[HTML][HTML] The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges
A fundamental shift in neuroscience suggests bidirectional interaction of gut microbiota with
the healthy and dysfunctional brain. This microbiota-gut-brain axis has mainly been …
the healthy and dysfunctional brain. This microbiota-gut-brain axis has mainly been …
Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications
Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …
economic problem around the globe. The development of therapeutic strategies for CNS …
Antibiotics and mental health: The good, the bad and the ugly
Antibiotics are recognised as, on occasion, producing psychiatric side effects, most notably
depression and anxiety. Apart from antimicrobial activity, antibiotics have multiple off‐target …
depression and anxiety. Apart from antimicrobial activity, antibiotics have multiple off‐target …
Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers
The emerging concept of psychobiotics—live microorganisms with a potential mental health
benefit—represents a novel approach for the management of stress-related conditions. The …
benefit—represents a novel approach for the management of stress-related conditions. The …
A systematic review of the psychobiological burden of informal caregiving for patients with dementia: Focus on cognitive and biological markers of chronic stress
As the physiological impact of chronic stress is difficult to study in humans, naturalistic
stressors are invaluable sources of information in this area. This review systematically …
stressors are invaluable sources of information in this area. This review systematically …
A psychology of the human brain–gut–microbiome axis
In recent years, we have seen increasing research within neuroscience and biopsychology
on the interactions between the brain, the gastrointestinal tract, the bacteria within the …
on the interactions between the brain, the gastrointestinal tract, the bacteria within the …