The role of genetics in advancing precision medicine for Alzheimer's disease—a narrative review
Alzheimer's disease (AD) is the most common type of dementia, which has a substantial
genetic component. AD affects predominantly older people. Accordingly, the prevalence of …
genetic component. AD affects predominantly older people. Accordingly, the prevalence of …
Antibody therapy targeting RAN proteins rescues C9 ALS/FTD phenotypes in C9orf72 mouse model
The intronic C9orf72 G4C2 expansion, the most common genetic cause of ALS and FTD,
produces sense-and antisense-expansion RNAs and six dipeptide repeat-associated, non …
produces sense-and antisense-expansion RNAs and six dipeptide repeat-associated, non …
Genetic analyses of early-onset Alzheimer's disease using next generation sequencing
Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein …
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein …
Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches
Z Firdaus, X Li - International journal of molecular sciences, 2024 - mdpi.com
Genetic abnormalities play a crucial role in the development of neurodegenerative disorders
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington
University in St. Louis has pioneered and led worldwide seminal studies that have …
University in St. Louis has pioneered and led worldwide seminal studies that have …
Genome sequence analyses identify novel risk loci for multiple system atrophy
Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by
parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is …
parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is …
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
Background Low frequency coding variants in TREM2 are associated with Alzheimer
disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between …
disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between …
Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA …
C Luciano, DD Fernando, Z Lucia, I Elvira… - Clinical …, 2024 - Springer
Background The epigenetic status of patients 6-month post-COVID-19 infection remains
largely unexplored. The existence of long-COVID, or post-acute sequelae of SARS-CoV-2 …
largely unexplored. The existence of long-COVID, or post-acute sequelae of SARS-CoV-2 …
Analysis of 50 neurodegenerative genes in clinically diagnosed early-onset Alzheimer's disease
Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and prion diseases have a …
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and prion diseases have a …
Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease
Abstract Background Autosomal-dominant Alzheimer's disease (ADAD) is caused by
pathogenic mutations in APP, PSEN1, and PSEN2, which usually lead to an early age at …
pathogenic mutations in APP, PSEN1, and PSEN2, which usually lead to an early age at …