Deep eutectic solvents (DES) are multicomponent liquids that are usually formed by
coupling a hydrogen bond donor and acceptor leading to strong non-covalent (NC) …

Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …

Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

Cocrystals can be used as an alternative approach based on crystal engineering to enhance
specific physicochemical and biopharmaceutical properties of active pharmaceutical …

Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules
and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the …

Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …

Cocrystals are homogenous (single-phase) crystalline structures composed by two or more
components in a definite stoichiometric ratio bonded together by noncovalent bonds …

The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid
pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the …

Cocrystal engineering is gaining interest across various disciplines since it can effectively
tune the properties of solid substances via noncovalent synthesis by introducing new …