Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) are diseases that can be
influenced by the structure of gut microbiota, whose improvement is often neglected in …

Type 2 diabetes mellitus (T2DM) remains one of the most problematic and economic
consumer disorders worldwide, with growing prevalence and incidence. Over the last years …

Faecalibacterium prausnitzii (F. prausnitzii) is one of the most abundant bacterial species in
the colon of healthy human adults and representing more than 5% of the total bacterial …

Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM);
however, its mechanism of modulating glucose metabolism is elusive. Recent advances …

Parkinson's disease (PD) is the most common progressive neurological disorder
compromising motor functions. However, nonmotor symptoms, such as gastrointestinal (GI) …

Mounting evidence suggested that the gut microbiota has a significant role in the
metabolism and disease status of the host. In particular, Type 2 Diabetes (T2D), which has a …

The decline in cognitive function and the prevalence of neurodegenerative disorders are
among the most serious threats to health in old age. The prevalence of dementia has …