MitoTALEN: a general approach to reduce mutant mtDNA loads and restore oxidative phosphorylation function in mitochondrial diseases
M Hashimoto, SR Bacman, S Peralta, MJ Falk… - Molecular Therapy, 2015 - cell.com
We have designed mitochondrially targeted transcription activator-like effector nucleases or
mitoTALENs to cleave specific sequences in the mitochondrial DNA (mtDNA) with the goal …
mitoTALENs to cleave specific sequences in the mitochondrial DNA (mtDNA) with the goal …
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells
V Tosato, NM Grüning, M Breitenbach, R Arnak… - Frontiers in …, 2013 - frontiersin.org
Yeast has been established as an efficient model system to study biological principles
underpinning human health. In this review we focus on yeast models covering two aspects …
underpinning human health. In this review we focus on yeast models covering two aspects …
The use of mitochondria-targeted endonucleases to manipulate mtDNA
For more than a decade, mitochondria-targeted nucleases have been used to promote
double-strand breaks in the mitochondrial genome. This was done in mitochondrial DNA …
double-strand breaks in the mitochondrial genome. This was done in mitochondrial DNA …
[HTML][HTML] Per aspera ad astra: When harmful chromosomal translocations become a plus value in genetic evolution. Lessons from Saccharomyces cerevisiae.
V Tosato, CV Bruschi - Microbial Cell, 2015 - ncbi.nlm.nih.gov
In this review we will focus on chromosomal translocations (either spontaneous or induced)
in budding yeast. Indeed, very few organisms tolerate so well aneuploidy like …
in budding yeast. Indeed, very few organisms tolerate so well aneuploidy like …
Rad59 regulates association of Rad52 with DNA double‐strand breaks
Homologous recombination among repetitive sequences is an important mode of DNA
repair in eukaryotes following acute radiation exposure. We have developed an assay in S …
repair in eukaryotes following acute radiation exposure. We have developed an assay in S …
A new scheme to artificially alter yeast mating-types without autodiploidization
N Fukuda - Fungal Genetics and Biology, 2020 - Elsevier
Sexual hybridization can drive dramatic yeast evolution through the inheritance of genomic
information from each parental cell. Unfortunately, however, a pair of strains, MATa and …
information from each parental cell. Unfortunately, however, a pair of strains, MATa and …
An Assay to Study Intra-Chromosomal Deletions in Yeast
BE Lucas, MT McPherson, TM Hawk, LN Wilson… - Methods and …, 2019 - mdpi.com
An accurate DNA damage response pathway is critical for the repair of DNA double-strand
breaks. Repair may occur by homologous recombination, of which many different sub …
breaks. Repair may occur by homologous recombination, of which many different sub …
Unwinding Pathways: The Role of Sgs1 and Mph1 in DNA Repair and Mismatch Correction
MF Afreen - 2021 - search.proquest.com
Double strand breaks (DSBs) can occur in the genome from regular cellular processes and
environmental, clastogenic agents. Failure and error in repairing DSBs results in genome …
environmental, clastogenic agents. Failure and error in repairing DSBs results in genome …
[PDF][PDF] Genetic Requirements for Intra-Chromosomal Deletions
MT McPherson, B Lucas, R Petreaca - 2020 - kb.osu.edu
Chromosomal deletions are one of the most dangerous types of DNA damage and often
arise as a result of inappropriately repaired DNA double strand breaks (DSB). These breaks …
arise as a result of inappropriately repaired DNA double strand breaks (DSB). These breaks …
[LIVRE][B] The Homologous Recombination Gene, RAD59, is a Determinant of Genome Stability in Saccharomyces cerevisiae
LC Liddell - 2014 - search.proquest.com
Rad59 is a DNA repair protein involved in double-strand break repair (DSBR) by
homologous recombination (HR) in Saccharomyces cerevisiae. Rad59 aids the central HR …
homologous recombination (HR) in Saccharomyces cerevisiae. Rad59 aids the central HR …