Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

AN Brandebura, A Paumier, TS Onur… - Nature Reviews …, 2023 - nature.com
There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

Elusive roles for reactive astrocytes in neurodegenerative diseases

L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …

[HTML][HTML] The multi-dimensional roles of astrocytes in ALS

K Yamanaka, O Komine - Neuroscience research, 2018 - Elsevier
Despite significant progress in understanding the molecular and genetic aspects of
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

AG Orr, EC Hsiao, MM Wang, K Ho, DH Kim… - Nature …, 2015 - nature.com
Astrocytes express a variety of G protein–coupled receptors and might influence cognitive
functions, such as learning and memory. However, the roles of astrocytic Gs-coupled …

Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure

J Szymański, J Janikiewicz, B Michalska… - International Journal of …, 2017 - mdpi.com
Studying organelles in isolation has been proven to be indispensable for deciphering the
underlying mechanisms of molecular cell biology. However, observing organelles in intact …

SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells

C Peggion, V Scalcon, ML Massimino, K Nies… - Antioxidants, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …

Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis

AA Almad, A Doreswamy, SK Gross, JP Richard, Y Huo… - Glia, 2016 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of motor neurons in the CNS. Astrocytes play a critical role in disease …

Resveratrol: a focus on several neurodegenerative diseases

E Tellone, A Galtieri, A Russo… - … medicine and cellular …, 2015 - Wiley Online Library
Molecules of the plant world are proving their effectiveness in countering, slowing down, and
regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene …

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

SP Allen, B Hall, LM Castelli, L Francis, R Woof… - Brain, 2019 - academic.oup.com
As clinical evidence supports a negative impact of dysfunctional energy metabolism on the
disease progression in amyotrophic lateral sclerosis, it is vital to understand how the energy …