Astrocytes in human central nervous system diseases: a frontier for new therapies
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …
and defence of the central nervous system (CNS). Astroglia contribute to the …
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
AN Brandebura, A Paumier, TS Onur… - Nature Reviews …, 2023 - nature.com
There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …
Elusive roles for reactive astrocytes in neurodegenerative diseases
L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …
response. They become reactive in response to virtually all pathological situations in the …
[HTML][HTML] The multi-dimensional roles of astrocytes in ALS
Despite significant progress in understanding the molecular and genetic aspects of
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory
AG Orr, EC Hsiao, MM Wang, K Ho, DH Kim… - Nature …, 2015 - nature.com
Astrocytes express a variety of G protein–coupled receptors and might influence cognitive
functions, such as learning and memory. However, the roles of astrocytic Gs-coupled …
functions, such as learning and memory. However, the roles of astrocytic Gs-coupled …
Interaction of mitochondria with the endoplasmic reticulum and plasma membrane in calcium homeostasis, lipid trafficking and mitochondrial structure
J Szymański, J Janikiewicz, B Michalska… - International Journal of …, 2017 - mdpi.com
Studying organelles in isolation has been proven to be indispensable for deciphering the
underlying mechanisms of molecular cell biology. However, observing organelles in intact …
underlying mechanisms of molecular cell biology. However, observing organelles in intact …
SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of motor neurons in the CNS. Astrocytes play a critical role in disease …
progressive loss of motor neurons in the CNS. Astrocytes play a critical role in disease …
Resveratrol: a focus on several neurodegenerative diseases
E Tellone, A Galtieri, A Russo… - … medicine and cellular …, 2015 - Wiley Online Library
Molecules of the plant world are proving their effectiveness in countering, slowing down, and
regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene …
regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene …
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
As clinical evidence supports a negative impact of dysfunctional energy metabolism on the
disease progression in amyotrophic lateral sclerosis, it is vital to understand how the energy …
disease progression in amyotrophic lateral sclerosis, it is vital to understand how the energy …