Comprehensive insights into medicinal research on imidazole-based supramolecular complexes

SR Li, YM Tan, L Zhang, CH Zhou - Pharmaceutics, 2023 - mdpi.com
The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two
nitrogen atoms, is an important functional fragment widely present in a large number of …

Correlation of the anticancer and pro-oxidant behavior and the structure of flavonoid-oxidovanadium (IV) complexes

LG Naso, EG Ferrer, PAM Williams - Coordination Chemistry Reviews, 2023 - Elsevier
The phytochemical compounds flavonoids have potential medicinal benefits such as
antioxidant, anti-inflammatory, anticancer and antiviral action. These properties can be …

Tumor Microenvironment‐Responsive Nanocarrier Based on VOx Nanozyme Amplify Oxidative Stress for Tumor Therapy

F Zhang, K Cheng, ZY Huang, XL Hou… - Advanced Functional …, 2023 - Wiley Online Library
The construction of a novel nanocarrier that can break the redox balance in tumor cell is a
promising anti‐tumor strategy. Herein, a tumor microenvironment (TME)‐responsive …

LVVO-Ethyl Maltol-Based Metallodrugs (L2– = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis

G Sahu, SA Patra, PD Pattanayak… - Inorganic …, 2023 - ACS Publications
Four new oxidovanadium [VVOL1–4 (ema)] complexes (1–4) have been synthesized using
tridentate binegative ONO donor ligands H2L1–4 [H2L1:(E)-N′-(2-hydroxybenzylidene) …

Isorhamnetin exerts anti-tumor activity in DEN + CCl4-induced HCC mice

S Sarkar, AK Das, S Bhattacharya, R Gachhui, PC Sil - Medical Oncology, 2023 - Springer
Background Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer and
the main cause of cancer death globally. The use of medicinal herbs as chemotherapeutic …

Synthesis, characterization, and evaluation of in vitro cytotoxicity and in vivo antitumor activity of asiatic acid-loaded poly lactic-co-glycolic acid nanoparticles: A …

S Dutta, P Chakraborty, S Basak, S Ghosh, N Ghosh… - Life Sciences, 2022 - Elsevier
Asiatic acid (AA), an aglycone of pentacyclic triterpene glycoside, obtained from the leaves
of Centella asiatica exerts anticancer effects by inhibiting cellular proliferation and inducing …

Glycobiology of cellular expiry: decrypting the role of glycan-lectin regulatory complex and therapeutic strategies focusing on cancer

AK Das, N Ghosh, A Mandal, PC Sil - Biochemical Pharmacology, 2023 - Elsevier
Often the outer leaflets of living cells bear a coat of glycosylated proteins, which primarily
regulates cellular processes. Glycosylation of such proteins occurs as part of their post …

Lactoferrin Nanoparticle-Vanadium Complex: A Promising High-Efficiency Agent against Glioblastoma by Triggering Autophagy and Ferroptosis

S Gai, Q Yan, S Li, X Zhong, Y Qin… - Journal of Medicinal …, 2025 - ACS Publications
Glioblastoma represents the most aggressive type of brain cancer with minimal clinical
advancements in recent decades attributed to the absence of efficient drug delivery …

pH-responsive and targeted delivery of chrysin via folic acid-functionalized mesoporous silica nanocarrier for breast cancer therapy

N Ghosh, M Kundu, S Ghosh, AK Das, S De… - International Journal of …, 2023 - Elsevier
Cancer is a disease of global importance. In order to mitigate conventional chemotherapy-
related side effects, phytochemicals with inherent anticancer efficacy have been opted …

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis …

SM Hefny, TF El-Moselhy, N El-Din, A Ammara… - European Journal of …, 2024 - Elsevier
Herein, we describe the design and synthesis of novel aryl pyrimidine benzenesulfonamides
APBSs 5a-n, 6a-c, 7a-b, and 8 as pazopanib analogues to explore new potent and selective …