Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

Burkitt lymphoma (BL) is an aggressive form of B cell lymphoma that can affect children and
adults. The study of BL led to the identification of the first recurrent chromosomal aberration …

The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …

The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …