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Approved antiviral drugs over the past 50 years
E De Clercq, G Li - Clinical microbiology reviews, 2016 - journals.asm.org
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …
categorized into 13 functional groups have been formally approved for the treatment of the …
HIV infection
More than 75 million people worldwide have been infected with human immunodeficiency
virus (HIV), and there are now approximately 37 million individuals living with the infection …
virus (HIV), and there are now approximately 37 million individuals living with the infection …
Dolutegravir or darunavir in combination with zidovudine or tenofovir to treat HIV
NI Paton, J Musaazi, C Kityo, S Walimbwa… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background The World Health Organization recommends dolutegravir with two
nucleoside reverse-transcriptase inhibitors (NRTIs) for second-line treatment of human …
nucleoside reverse-transcriptase inhibitors (NRTIs) for second-line treatment of human …
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2016 recommendations of the International Antiviral Society–USA panel
Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …
Efficacy, safety, and tolerability of dolutegravir-rilpivirine for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority …
Background Lifelong HIV antiretroviral therapy (ART) has prompted an interest in two-drug
regimens to minimise cumulative drug exposure and toxicities. The safety, tolerability, and …
regimens to minimise cumulative drug exposure and toxicities. The safety, tolerability, and …
Coformulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 …
PE Sax, A Pozniak, ML Montes, E Koenig, E DeJesus… - The Lancet, 2017 - thelancet.com
Background Integrase strand transfer inhibitors (INSTIs) coadministered with two nucleoside
or nucleotide reverse transcriptase inhibitors (NRTIs) are recommended as first-line …
or nucleotide reverse transcriptase inhibitors (NRTIs) are recommended as first-line …
Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and …
Background Effective two-drug regimens could decrease long-term drug exposure and
toxicity with HIV-1 antiretroviral therapy (ART). We therefore aimed to evaluate the efficacy …
toxicity with HIV-1 antiretroviral therapy (ART). We therefore aimed to evaluate the efficacy …
Brief report: weight gain in persons with HIV switched from efavirenz-based to integrase strand transfer inhibitor–based regimens
J Norwood, M Turner, C Bofill, P Rebeiro… - JAIDS Journal of …, 2017 - journals.lww.com
Background: With the introduction of integrase strand transfer inhibitor (INSTI)-based
antiretroviral therapy, persons living with HIV have a potent new treatment option. Recently …
antiretroviral therapy, persons living with HIV have a potent new treatment option. Recently …
Higher rates of neuropsychiatric adverse events leading to dolutegravir discontinuation in women and older patients
C Hoffmann, T Welz, M Sabranski, M Kolb, E Wolf… - HIV …, 2017 - Wiley Online Library
Objectives Dolutegravir (DTG), a second‐generation integrase strand transfer inhibitor
(INSTI), is now among the most frequently used antiretroviral agents. However, recent …
(INSTI), is now among the most frequently used antiretroviral agents. However, recent …
Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society–USA Panel
Importance New data and antiretroviral regimens expand treatment choices in resource-rich
settings and warrant an update of recommendations to treat adults infected with human …
settings and warrant an update of recommendations to treat adults infected with human …