Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Chronic inflammation and an immunosuppressive microenvironment promote prostate
cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) …

Emerging evidence suggests that USP39 plays an important role in the development of
hepatocellular carcinoma (HCC). However, the molecular mechanism by which USP39 …

Ovarian cancer is an aggressive gynecological tumor characterized by a high relapse rate
and chemoresistance. Ovarian cancer exhibits the cancer hallmark of elevated glycolysis …

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins
related to cell growth, proliferation, and survival. Of the ubiquitination system components …

Background Recent studies have indicated that some members of the tripartite motif (TRIM)
proteins function as important regulators for non-small cell lung cancer (NSCLC), However …

Oral and esophageal squamous cell carcinomas (SCCs) are associated with high mortality,
yet the molecular mechanisms underlying these malignancies are largely unclear. We show …

Amino acids are essential for the activation of the mechanistic target of rapamycin (mTOR),
but the corresponding molecular mechanism is not yet fully understood. We previously found …