Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides

DR Nässel, JV Broeck - Cellular and Molecular Life Sciences, 2016‏ - Springer
Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important
regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF …

Insulin signaling and the regulation of insect diapause

C Sim, DL Denlinger - Frontiers in physiology, 2013‏ - frontiersin.org
A rich chapter in the history of insect endocrinology has focused on hormonal control of
diapause, especially the major roles played by juvenile hormones (JHs), ecdysteroids, and …

Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

DE Neafsey, RM Waterhouse, MR Abai, SS Aganezov… - Science, 2015‏ - science.org
INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and …

N Kapan, OV Lushchak, J Luo, DR Nässel - Cellular and Molecular Life …, 2012‏ - Springer
Insulin/IGF-like signaling regulates the development, growth, fecundity, metabolic
homeostasis, stress resistance and lifespan in worms, flies and mammals. Eight insulin-like …

Insulin-Producing Cells in the Drosophila Brain also Express Satiety-Inducing Cholecystokinin-Like Peptide, Drosulfakinin

JAE Söderberg, MA Carlsson, DR Nässel - Frontiers in endocrinology, 2012‏ - frontiersin.org
Regulation of meal size and assessing the nutritional value of food are two important
aspects of feeding behavior. The mechanisms that regulate these two aspects have not …

Nutrition-dependent control of insect development by insulin-like peptides

N Okamoto, N Yamanaka - Current opinion in insect science, 2015‏ - Elsevier
Highlights•Insulin-like peptides (ILPs) are encoded by multiple genes in insects.•Insect ILPs
are mainly produced by the brain medial neurosecretory cells (mNSCs).•Transcription and …

Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

L Kučerová, OI Kubrak, JM Bengtsson, H Strnad… - BMC genomics, 2016‏ - Springer
Background In models extensively used in studies of aging and extended lifespan, such as
C. elegans and Drosophila, adult senescence is regulated by gene networks that are likely …

Photoperiod and temperature separately regulate nymphal development through JH and insulin/TOR signaling pathways in an insect

T Miki, T Shinohara, S Chafino, S Noji… - Proceedings of the …, 2020‏ - pnas.org
Insects living in the temperate zone enter a physiological state of arrested or slowed
development to overcome an adverse season, such as winter. Developmental arrest, called …

Gene Expression Dynamics in Major Endocrine Regulatory Pathways along the Transition from Solitary to Social Life in a Bumblebee, Bombus terrestris

P Jedlička, UR Ernst, A Votavová, R Hanus… - Frontiers in …, 2016‏ - frontiersin.org
Understanding the social evolution leading to insect eusociality requires, among other, a
detailed insight into endocrine regulatory mechanisms that have been co-opted from solitary …

Ovary ecdysteroidogenic hormone functions independently of the insulin receptor in the yellow fever mosquito, Aedes aegypti

A Dhara, JH Eum, A Robertson, M Gulia-Nuss… - Insect biochemistry and …, 2013‏ - Elsevier
Most mosquito species must feed on the blood of a vertebrate host to produce eggs. In the
yellow fever mosquito, Aedes aegypti, blood feeding triggers medial neurosecretory cells in …