Antioxidant effects of statins by modulating Nrf2 and Nrf2/HO-1 signaling in different diseases

A Mansouri, Ž Reiner, M Ruscica… - Journal of clinical …, 2022 - mdpi.com
Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and
have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four …

Retinal vascular caliber: systemic, environmental, and genetic associations

C Sun, JJ Wang, DA Mackey, TY Wong - Survey of ophthalmology, 2009 - Elsevier
Quantitative studies of retinal vascular caliber using new computer-assisted retinal imaging
systems have allowed physicians and researchers to understand the influence of systemic …

Atorvastatin-eluting contact lenses: effects of molecular imprinting and sterilization on drug loading and release

AF Pereira-da-Mota, M Vivero-Lopez, A Topete… - Pharmaceutics, 2021 - mdpi.com
Statins are receiving increasing attention in the ophthalmic field. Their activity as 3-hydroxy-
3-methylglutaryl–CoA (HMG–CoA) reductase inhibitors is clinically used to regulate …

Diabetes, metabolic abnormalities, and glaucoma: the Singapore Malay Eye Study

GS Tan, TY Wong, CW Fong… - Archives of …, 2009 - jamanetwork.com
Objective To examine the relationship of diabetes mellitus and metabolic abnormalities with
intraocular pressure and glaucoma. Methods A population-based study was conducted in …

Glaucoma is associated with peripheral vascular endothelial dysfunction

WW Su, ST Cheng, WJ Ho, PK Tsay, SC Wu… - Ophthalmology, 2008 - Elsevier
PURPOSE: To evaluate peripheral vascular endothelial function in patients with normal-
tension glaucoma (NTG) and primary open-angle glaucoma (POAG) using noninvasive …

Cholesterol-lowering drugs and incident open-angle glaucoma: a population-based cohort study

MW Marcus, RPHM Müskens, WD Ramdas… - PloS one, 2012 - journals.plos.org
Background Open-angle glaucoma (OAG) is a progressive neurodegenerative disease that
may lead to blindness. An elevated intraocular pressure (IOP) is its major risk factor. OAG …