The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components
and plays a significant role in tumor initiation, progression, metastasis, and response to …

The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Accurate in silico determination of CD8+ T cell epitopes would greatly enhance T cell-based
vaccine development, but current prediction models are not reliably successful. Here …

HLA class II antigen presentation is modulated by the activity of the peptide editor HLA-DM
and its antagonist HLA-DO, with their interplay controlling the peptide repertoires presented …

The identification of immunogenic peptides has become essential in an increasing number
of fields in immunology, ranging from tumor immunotherapy to vaccine development. The …

The strong association of the human leukocyte antigen B∗ 27 alleles (HLA-B∗ 27) with
spondyloarthritis and related rheumatic conditions has long fascinated researchers, yet the …

MHC-II molecules are key mediators of antigen presentation in vertebrate species and bind
to their ligands with high specificity. The very high polymorphism of MHC-II genes within …

Background. The development of de novo donor-specific antibodies (dnDSA) and antibody-
mediated rejection (AMR) remains a barrier to long-term graft and patient survival. Most …

Cytotoxic Th1 cells mushroom after fungal exposures in Crohn’s disease: Immunity Skip to
Main Content Advertisement Immunity This journal offers authors two options (open access or …