Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

The physical stability of solid-state forms in which drugs may exist is in some sense an
overlooked aspect. In an era where strategies such as amorphous solid dispersions or co …

Mechanochemistry deals with reactions induced by the input of mechanical energy–for
example by impacts within a vibratory ball mill. The technique has a long history with …

The dissociation at high humidity of cocrystals formed between caffeine and theophylline
with a series of dicarboxylic acids is investigated and found to be driven by the partial …

Naringenin, commonly found in citrus fruits, is one of the active pharmaceutical ingredient
(API) in naringenin-carbamazepine drug-drug cocrystal (NR-CBZ). In the preparation of …

There is, at present, a substantial lack of mechanistic-level understanding of
mechanochemical processes, despite their current widespread use. The system α-glycine+ …

Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated
in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary …

The stability of theophylline cocrystals composed of acidic (glutaric acid), basic
(isonicotinamide), or neutral (benzamide) coformers was evaluated in the presence of …

Fisetin, luteolin and genistein, natural polyphenolic compounds of pharmaceutical interest,
were combined with nicotinamide and isonicotinamide with an aim to obtain their cocrystals …

Enzalutamide (Enz), sold under the brand name “XTANDI”, belongs to a group of drugs
known as androgen receptor inhibitors and functions by suppressing androgen's actions …