Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
The sirtuin family in health and disease
QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
JA Amorim, G Coppotelli, AP Rolo… - Nature Reviews …, 2022 - nature.com
Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Hyperglycemia and oxidative stress: An integral, updated and critical overview of their metabolic interconnections
P González, P Lozano, G Ros, F Solano - International Journal of …, 2023 - mdpi.com
This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …
[HTML][HTML] Telomeres: history, health, and hallmarks of aging
D Chakravarti, KA LaBella, RA DePinho - Cell, 2021 - cell.com
The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
Oxidative stress in oocyte aging and female reproduction
L Wang, J Tang, L Wang, F Tan, H Song… - Journal of cellular …, 2021 - Wiley Online Library
In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …
[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
R Mattioli, A Ilari, B Colotti, L Mosca, F Fazi… - Molecular Aspects of …, 2023 - Elsevier
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …
SIRT1 and aging related signaling pathways
C Chen, M Zhou, Y Ge, X Wang - Mechanisms of ageing and development, 2020 - Elsevier
Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …
with the increasing of age. It has become a major risk factor of human diseases, including …