Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Although connections between cognitive deficits and age-associated brain differences have
been elucidated, relationships with motor performance are less well understood. Here, we …

Quantifying the microstructural properties of the human brain's connections is necessary for
understanding normal ageing and disease. Here we examine brain white matter magnetic …

Objective: We determined whether Gram-negative bacterial molecules are associated with
Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram …

Aims Several factors are known to increase risk for cerebrovascular disease and dementia,
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …

The macro-and microstructural architecture of human brain white matter undergoes
substantial alterations throughout development and ageing. Most of our understanding of …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Brain aging research relies mostly on cross-sectional studies, which infer true changes from
age differences. We present longitudinal measures of five-year change in the regional brain …

Memory decline in aging results from multiple factors that influence both executive function
and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems …

In this article we review recent research on diffusion tensor imaging (DTI) of white matter
(WM) integrity and the implications for age-related differences in cognition. Neurobiological …