Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

The theta rhythm is one of the largest and most sinusoidal activity patterns in the brain. Here
I survey progress in the field of theta rhythms research. I present arguments supporting the …

Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Our understanding of the molecular properties of kainate receptors and their involvement in
synaptic physiology has progressed significantly over the last 30 years. A plethora of studies …

Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …

Functional kainate receptors are ubiquitous in the central nervous system. After a search for
their functional significance, a considerable amount of data indicates that this class of …

Domoic acid was identified as the toxin responsible for an outbreak of human poisoning that
occurred in Canada in 1987 following consumption of contaminated blue mussels [Mytilus …

Excitatory glutamatergic transmission involves a variety of different receptor types, each with
distinct properties and functions. Physiological studies have identified both post-and …