Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired
drug resistance hinders clinical efficacy and leads to treatment failure in most patients …

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

Functional proteins in the cell are translated from the messenger RNA (mRNA) molecules,
constituting less than 5% of the cellular transcriptome. The majority of the RNA molecules in …

Globally, colorectal cancer (CRC) is the third most prevalent cancer and the second leading
cause of cancer-related deaths. Circular RNAs (circRNAs) are single-stranded RNA with …

The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …

Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly
facilitated by base-pairing of reverse complementary matches (RCMs) in circRNA flanking …

Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …