Gilbert's syndrome revisited

L Vítek, C Tiribelli - Journal of hepatology, 2023 - Elsevier
Gilbert's syndrome, also known as benign hyperbilirubinaemia, was described more than
100 years ago. It has usually been considered a physiological abnormality characterised by …

[HTML][HTML] Bilirubin as a therapeutic molecule: challenges and opportunities

CA Adin - Antioxidants, 2021 - mdpi.com
There is strong evidence that serum free bilirubin concentration has significant effects on
morbidity and mortality in the most significant health conditions of our times, including …

Bilirubin safeguards cardiorenal and metabolic diseases: a protective role in health

TD Hinds Jr, DE Stec - Current hypertension reports, 2019 - Springer
Abstract Purpose of Review To discuss recent advances indicating that bilirubin safeguards
against cardiorenal and metabolic diseases. Recent Findings Several investigations from …

Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea

AC Bulmer, B Bakrania, EF Du Toit… - American Journal …, 2018 - journals.physiology.org
Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency,
exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's …

[HTML][HTML] Unconjugated hyperbilirubinemia

A Singh, T Koritala, I Jialal - 2019 - europepmc.org
Objectives: Describe the physiology of bilirubin metabolism. Explain how to differentiate
unconjugated hyperbilirubinemia from conjugated hyperbilirubinemia. Identify the several …

Beyond a measure of liver function—bilirubin acts as a potential cardiovascular protector in chronic kidney disease patients

MT Tsai, DC Tarng - International journal of molecular sciences, 2018 - mdpi.com
Bilirubin is a well-known neurotoxin in newborn infants; however, current evidence has
shown that a higher serum bilirubin concentration in physiological ranges is associated with …

Heme oxygenase dependent bilirubin generation in vascular cells: a role in preventing endothelial dysfunction in local tissue microenvironment?

M Nitti, AL Furfaro, GE Mann - Frontiers in Physiology, 2020 - frontiersin.org
Among antioxidants in the human body, bilirubin has been recognized over the past 20
years to afford protection against different chronic conditions, including inflammation and …

Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications

JJ DiNicolantonio, MF McCarty, JH O'Keefe - Open Heart, 2018 - openheart.bmj.com
Gilbert syndrome (GS) is a common genetic variant in which plasma unconjugated bilirubin
levels are elevated throughout life, in the absence of hepatic pathology. 1 This typically …

Relation between unconjugated bilirubin and peripheral biomarkers of inflammation derived from complete blood counts in patients with acute stage of schizophrenia

H Xu, Y Wei, L Zheng, H Zhang, T Luo, H Li… - Frontiers in …, 2022 - frontiersin.org
Background Inflammation and oxidative stress are the major leading hypothetical causes of
schizophrenia. Unconjugated bilirubin (UCB) is an efficient endogenous plasma antioxidant …

Bilirubin elevation during hospitalization post radiofrequency catheter ablation of persistent atrial fibrillation: Variation trend, related factors, and relevance to 1-year …

JM Shao, B Shen, ZX Zhou, L D'Angelo… - … Interventions in Aging, 2024 - Taylor & Francis
Background The role of total bilirubin (TBIL) in cardiovascular disease has been
increasingly recognized in recent decades. Studies have shown a correlation between total …