The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases
(MMPs) as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and …

A compelling long-term goal of cancer biology is to understand the crucial players during
tumorigenesis in order to develop new interventions. Here, we review how the four non …

A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Inhibitors of matrix metalloproteinases (MMPs) have been extensively explored to treat
pathologies where excessive MMP activity contributes to adverse tissue remodelling …

Matrix metalloproteinases (MMPs), also designated matnxms, are a family of related zinc
metalloendopeptidases that function in the turnover of components of the extracellular …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Tissue inhibitors of metalloproteinases (TIMPs) are the major cellular inhibitors of the matrix
metalloproteinase (MMP) sub-family, exhibiting varying efficacy against different members …

Metastatic spread of cancer continues to be the greatest barrier to cancer cure.
Understanding the molecular mechanisms of metastasis is crucial for the design and …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …