Curcumin: an inflammasome silencer
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
[HTML][HTML] The NLRP3 inflammasome: regulation by metabolic signals
A Olona, S Leishman, PK Anand - Trends in Immunology, 2022 - cell.com
Macrophages undergo profound metabolic reprogramming upon sensing infectious and
sterile stimuli. This metabolic shift supports and regulates essential innate immune functions …
sterile stimuli. This metabolic shift supports and regulates essential innate immune functions …
Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
Investigation of pulmonary toxicity evaluation on mice exposed to polystyrene nanoplastics: the potential protective role of the antioxidant N-acetylcysteine
Y Wu, Y Yao, H Bai, K Shimizu, R Li, C Zhang - Science of the total …, 2023 - Elsevier
Accumulating evidences show that the hazardous substance atmospheric nanoplastics
increase the respiratory risk of individuals, but the inside toxicity mechanisms to lung tissue …
increase the respiratory risk of individuals, but the inside toxicity mechanisms to lung tissue …
Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS
Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated
macrophages and known to play an important role in metabolism and immunity. In this study …
macrophages and known to play an important role in metabolism and immunity. In this study …
Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
B Chen, H Li, G Ou, L Ren, X Yang, M Zeng - Arthritis research & therapy, 2019 - Springer
Background Gouty arthritis is characterized by the deposition of monosodium urate (MSU)
within synovial joints and tissues due to increased urate concentrations. In this study, we …
within synovial joints and tissues due to increased urate concentrations. In this study, we …
Dimethyl itaconate induces long-term innate immune responses and confers protection against infection
Itaconate is an immunomodulatory metabolite produced by immune cells under microbial
stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti …
stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti …
Mouse models for human hyperuricaemia: a critical review
Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates,
including in humans, because of inactivation of the gene encoding uricase during primate …
including in humans, because of inactivation of the gene encoding uricase during primate …
Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo
Iron is an essential metal that fine-tunes the innate immune response by regulating
macrophage function, but an integrative view of transcriptional and metabolic responses to …
macrophage function, but an integrative view of transcriptional and metabolic responses to …
Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity
H Darroch, P Keerthisinghe, YJ Sung, L Rolland… - Science …, 2023 - science.org
Hematopoietic stem and progenitor cells (HSPCs) respond to infection by proliferating and
generating in-demand neutrophils through a process called emergency granulopoiesis …
generating in-demand neutrophils through a process called emergency granulopoiesis …