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Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation …
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and
remains a formidable global health challenge. The current medication for AD gives …
remains a formidable global health challenge. The current medication for AD gives …
Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …
progressive cognitive decline and memory impairment. Despite advances in therapeutic …
Binding studies of potential amyloid-β inhibiting chalcone derivative with bovine serum albumin
S Daksh, C Gond, N Kumar, L Kaur, H Ojha… - … Acta Part A: Molecular …, 2024 - Elsevier
Abstract Chalcones (α-phenyl-β-benzoylethylene) and their natural-source derivatives have
been investigated for their remarkable biological activities, like neuroprotective, anti …
been investigated for their remarkable biological activities, like neuroprotective, anti …
Multiepitope glycan based laser assisted fluorescent nanocomposite with dual functionality for sensing and ablation of Pseudomonas aeruginosa
Pseudomonas aeruginosa (P. aeruginosa) infection is becoming a severe health hazard
and needs early diagnosis with high specificity. However, the non-specific binding of a …
and needs early diagnosis with high specificity. However, the non-specific binding of a …
Effect of cycloastragenol and punicalagin on prp (106–126) and Aβ (25–35) oligomerization and fibrillizaton
Numerous neurological disorders, including prion, Parkinson's, and Alzheimer's disease
(AD), are identified as being caused by alterations in protein conformation, aggregation, and …
(AD), are identified as being caused by alterations in protein conformation, aggregation, and …
[HTML][HTML] Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease
Alzheimer's disease (AD) remains a significant healthcare challenge, necessitating
innovative therapeutic approaches to address its complex and multifactorial nature …
innovative therapeutic approaches to address its complex and multifactorial nature …
Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353
The inhibition of amyloid-β (Aβ) fibrillation and clearance of Aβ aggregates have emerged
as a potential pharmacological strategy to alleviate Aβ aggregate-induced neurotoxicity in …
as a potential pharmacological strategy to alleviate Aβ aggregate-induced neurotoxicity in …
Peptide-based amyloid-beta aggregation inhibitors
N Sehra, R Parmar, R Jain - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …
Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ42 Fibrils
An effective therapeutic strategy to suppress Alzheimer's disease (AD) progression is to
disrupt β‐sheet rich neurotoxic soluble amyloid‐β (Aβ) aggregates. Previously, we identified …
disrupt β‐sheet rich neurotoxic soluble amyloid‐β (Aβ) aggregates. Previously, we identified …
Synthesis of metal-binding amino acids
KEV Deck, WDG Brittain - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
The ability for amino acid residues to bind metals underpins the functions of metalloproteins
to conduct a plethora of critical processes in living organisms as well as unnatural …
to conduct a plethora of critical processes in living organisms as well as unnatural …