Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation …

K Singh, A Kaur, B Goyal, D Goyal - ACS Chemical Neuroscience, 2024 - ACS Publications
Alzheimer's disease (AD) is a progressive multifaceted neurodegenerative disease and
remains a formidable global health challenge. The current medication for AD gives …

Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition

J Yoo, J Lee, B Ahn, J Han, MH Lim - Chemical Science, 2025 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative dementia, marked by
progressive cognitive decline and memory impairment. Despite advances in therapeutic …

Binding studies of potential amyloid-β inhibiting chalcone derivative with bovine serum albumin

S Daksh, C Gond, N Kumar, L Kaur, H Ojha… - … Acta Part A: Molecular …, 2024 - Elsevier
Abstract Chalcones (α-phenyl-β-benzoylethylene) and their natural-source derivatives have
been investigated for their remarkable biological activities, like neuroprotective, anti …

Multiepitope glycan based laser assisted fluorescent nanocomposite with dual functionality for sensing and ablation of Pseudomonas aeruginosa

P Garg, N Priyadarshi, MD Ambule, G Kaur, S Kaul… - Nanoscale, 2023 - pubs.rsc.org
Pseudomonas aeruginosa (P. aeruginosa) infection is becoming a severe health hazard
and needs early diagnosis with high specificity. However, the non-specific binding of a …

Effect of cycloastragenol and punicalagin on prp (106–126) and Aβ (25–35) oligomerization and fibrillizaton

GR Navale, R Chauhan, S Saini, P Roy, K Ghosh - Biophysical Chemistry, 2023 - Elsevier
Numerous neurological disorders, including prion, Parkinson's, and Alzheimer's disease
(AD), are identified as being caused by alterations in protein conformation, aggregation, and …

[HTML][HTML] Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

U Azam, MM Naseer, C Rochais - European Journal of Medicinal Chemistry, 2025 - Elsevier
Alzheimer's disease (AD) remains a significant healthcare challenge, necessitating
innovative therapeutic approaches to address its complex and multifactorial nature …

Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353

A Dabas, B Goyal - ACS Chemical Neuroscience, 2024 - ACS Publications
The inhibition of amyloid-β (Aβ) fibrillation and clearance of Aβ aggregates have emerged
as a potential pharmacological strategy to alleviate Aβ aggregate-induced neurotoxicity in …

Peptide-based amyloid-beta aggregation inhibitors

N Sehra, R Parmar, R Jain - RSC Medicinal Chemistry, 2025 - pubs.rsc.org
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar
of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …

Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ42 Fibrils

A Kaur, O Kaur Mankoo, D Rani, N Priyadarshi… - …, 2024 - Wiley Online Library
An effective therapeutic strategy to suppress Alzheimer's disease (AD) progression is to
disrupt β‐sheet rich neurotoxic soluble amyloid‐β (Aβ) aggregates. Previously, we identified …

Synthesis of metal-binding amino acids

KEV Deck, WDG Brittain - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
The ability for amino acid residues to bind metals underpins the functions of metalloproteins
to conduct a plethora of critical processes in living organisms as well as unnatural …