The global burden of cancer incidence, deaths and economic costs is steadily increasing
since several decades. Despite a massive allocation of research funds since the 1970s, no …

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

Genetic association data from national biobanks and large-scale association studies have
provided new prospects for understanding the genetic evolution of complex traits and …

Given the many small-effect loci uncovered by genome-wide association studies (GWAS),
polygenic scores have become central to genomic medicine, and have found application in …

We report genome-wide data from 33 Ashkenazi Jews (AJ), dated to the 14 th century,
obtained following a salvage excavation at the medieval Jewish cemetery of Erfurt …

We here present CLUES2, a full-likelihood method to infer natural selection from sequence
data that is an extension of the method CLUES. We make several substantial improvements …

This perspective draws on the record of ancient pathogen genomes and microbiomes
illuminating patterns of infectious disease over the course of the Holocene in order to …

Evidence for a reduction in stature between Mesolithic foragers and Neolithic farmers has
been interpreted as reflective of declines in health, however, our current understanding of …

The rules and structure of human culture impact health as much as genetics or environment.
To study these relationships, we combine ancient DNA (n= 230), skeletal metrics (n= 391) …

The transitions from foraging to farming and later to pastoralism in Stone Age Eurasia (c. 11-
3 thousand years before present, BP) represent some of the most dramatic lifestyle changes …