Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

Understanding the role of sensorimotor beta oscillations

J Barone, HE Rossiter - Frontiers in systems neuroscience, 2021 - frontiersin.org
Beta oscillations have been predominantly observed in sensorimotor cortices and basal
ganglia structures and they are thought to be involved in somatosensory processing and …

Neural signatures of hyperdirect pathway activity in Parkinson's disease

A Oswal, C Cao, CH Yeh, WJ Neumann… - Nature …, 2021 - nature.com
Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …

Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication

G Tinkhauser, A Pogosyan, H Tan, DM Herz, AA Kühn… - Brain, 2017 - academic.oup.com
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …

Emerging technologies for improved deep brain stimulation

H Cagnan, T Denison, C McIntyre, P Brown - Nature biotechnology, 2019 - nature.com
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …

Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease

G Tinkhauser, A Pogosyan, S Little, M Beudel, DM Herz… - Brain, 2017 - academic.oup.com
Adaptive deep brain stimulation uses feedback about the state of neural circuits to control
stimulation rather than delivering fixed stimulation all the time, as currently performed. In …

Insights into the mechanisms of deep brain stimulation

K Ashkan, P Rogers, H Bergman… - Nature Reviews …, 2017 - nature.com
Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of
neurological conditions, the underlying mechanisms of action have been elusive. Growing …

Cross-frequency coupling and intelligent neuromodulation

CH Yeh, C Zhang, W Shi, MT Lo… - Cyborg and bionic …, 2023 - spj.science.org
Cross-frequency coupling (CFC) reflects (nonlinear) interactions between signals of different
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …

Adaptive deep brain stimulation in advanced Parkinson disease

S Little, A Pogosyan, S Neal, B Zavala… - Annals of …, 2013 - Wiley Online Library
Objective Brain–computer interfaces (BCIs) could potentially be used to interact with
pathological brain signals to intervene and ameliorate their effects in disease states. Here …