[HTML][HTML] Understanding apoptosis and apoptotic pathways targeted cancer therapeutics
R Jan - Advanced pharmaceutical bulletin, 2019 - ncbi.nlm.nih.gov
Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …
Lung cancer: Biology and treatment options
H Lemjabbar-Alaoui, OUI Hassan, YW Yang… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Lung cancer remains the leading cause of cancer mortality in men and women in the US
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …
[HTML][HTML] A proteogenomic portrait of lung squamous cell carcinoma
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials
Z Niu, R **, Y Zhang, H Li - Signal Transduction and Targeted Therapy, 2022 - nature.com
Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …
Survivin at a glance
SP Wheatley, DC Altieri - Journal of cell science, 2019 - journals.biologists.com
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …
Phenotypic screening in cancer drug discovery—past, present and future
JG Moffat, J Rudolph, D Bailey - Nature reviews Drug discovery, 2014 - nature.com
There has been a resurgence of interest in the use of phenotypic screens in drug discovery
as an alternative to target-focused approaches. Given that oncology is currently the most …
as an alternative to target-focused approaches. Given that oncology is currently the most …
Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?
Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery
more than two decades ago, the use of survivin as a target for cancer therapeutics has …
more than two decades ago, the use of survivin as a target for cancer therapeutics has …
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-
19 outbreak. Currently, effective treatment options remain very limited for this disease; …
19 outbreak. Currently, effective treatment options remain very limited for this disease; …
Survivin small molecules inhibitors: recent advances and challenges
Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a
suppressor of apoptosis and plays a central role in cell division. Survivin has been …
suppressor of apoptosis and plays a central role in cell division. Survivin has been …
Inhibitors of apoptosis: clinical implications in cancer
Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …
main regulators of caspase activity and cell death. They are considered the main culprits in …