The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

M Heidary, A Ebrahimi Samangani… - Journal of clinical …, 2022 - Wiley Online Library
Background Azithromycin (AZM), sold under the name Zithromax, is classified as a
macrolide. It has many benefits due to its immunomodulatory, anti‐inflammatory, and …

Extensively drug-resistant Haemophilus influenzae – emergence, epidemiology, risk factors, and regimen

PY Su, AH Huang, CH Lai, HF Lin, TM Lin, CH Ho - BMC microbiology, 2020 - Springer
Abstract Background Concern about Haemophilus influenzae infection has been increasing
over recent decades. Given the emergence of H. influenzae with severe drug resistance, we …

Distribution and drug resistance of bacterial pathogens associated with lower respiratory tract infection in children and the effect of COVID‐19 on the distribution of …

X Zhu, T Ye, H Zhong, Y Luo, J Xu… - Canadian Journal of …, 2022 - Wiley Online Library
By studying the distribution and drug resistance of bacterial pathogens associated with
lower respiratory tract infection (LRTI) in children in Chengdu and the effect of the COVID‐19 …

Multiplex polymerase chain reaction detection of Streptococcus pneumoniae and Haemophilus influenzae and their antibiotic resistance in patients with community …

A Farajzadeh Sheikh, R Rahimi, H Meghdadi, A Alami… - BMC microbiology, 2021 - Springer
Background This study aimed to evaluate the occurrence of Streptococcus pneumoniae and
Haemophilus influenzae in sputum of patients with community-acquired pneumonia (CAP) …

Antimicrobial resistance of Haemophilus influenzae isolates from pediatric hospitals in Mainland China: report from the ISPED program, 2017–2019

M Zhou, P Fu, C Fang, S Shang, C Hua, C **g… - Indian Journal of …, 2021 - Elsevier
Purpose This study set out to determine the antimicrobial resistance trends of Haemophilus
influenzae isolates from pediatric hospitals in Mainland China, which would provide basis …

Bacterial epidemiology and antimicrobial resistance profiles of respiratory specimens of children with pneumonia in Hainan, China

W Mai, Y Liu, Q Meng, J Xu, J Wu - Infection and Drug Resistance, 2023 - Taylor & Francis
Purpose To investigate the bacterial species and antimicrobial susceptibility of respiratory
specimens of children with pneumonia in Hainan, China. Methods A total of 5017 …

[HTML][HTML] In-silico study of antisense oligonucleotide antibiotics

ES Chen, ES Ho - PeerJ, 2023 - peerj.com
Background The rapid emergence of antibiotic-resistant bacteria directly contributes to a
wave of untreatable infections. The lack of new drug development is an important driver of …

First global report about the prevalence of multi-drug resistant Haemophilus influenzae: a systematic review and meta-analysis

M Abavisani, M Keikha, M Karbalaei - BMC Infectious Diseases, 2024 - Springer
Background In recent decades, the prevalence of antibiotic resistance is increasing in
Haemophilus influenzae (Haemophilus influenzae), which poses important challenges to …

Particulate air pollution and respiratory Haemophilus influenzae infection in Mianyang, southwest China

S Zhang, X Chen, J Wang, C Dai, Y Gou… - … Science and Pollution …, 2021 - Springer
Particulate air pollution is correlated with many respiratory diseases. However, few studies
have focused on the relationship between air particulate exposure and respiratory …