Anticancer applications and pharmacological properties of piperidine and piperine: a comprehensive review on molecular mechanisms and therapeutic perspectives

S Mitra, U Anand, NK Jha, MS Shekhawat… - Frontiers in …, 2022 - frontiersin.org
Piperine and piperidine are the two major alkaloids extracted from black pepper (Piper
nigrum); piperidine is a heterocyclic moiety that has the molecular formula (CH2) 5NH. Over …

[HTML][HTML] Potential of natural products in osteosarcoma treatment: Focus on molecular mechanisms

M Tobeiha, A Rajabi, A Raisi, M Mohajeri… - Biomedicine & …, 2021 - Elsevier
Osteosarcoma is the most frequent type of bone cancer found in children and adolescents,
and commonly arises in the metaphyseal region of tubular long bones. Standard therapeutic …

Exploration of noncovalent interactions, chemical reactivity, and nonlinear optical properties of piperidone derivatives: a concise theoretical approach

M Khalid, A Ali, MFU Rehman, M Mustaqeem, S Ali… - ACS …, 2020 - ACS Publications
The organic compounds with a π-bond system lead to electric charge delocalization which
enables them to reveal fascinating nonlinear optical properties. Mono-carbonyl …

Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action

V Dzmitruk, A Szulc, D Shcharbin… - International journal of …, 2015 - Elsevier
This paper examines a perspective to use newly engineered nanomaterials as effective and
safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers …

Novel dissymmetric 3, 5-bis (arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo

N Li, WY **n, BR Yao, CH Wang, W Cong… - European Journal of …, 2018 - Elsevier
Abstract Thirty-five novel dissymmetric 3, 5-bis (arylidene)-4-piperidone derivatives (BAPs,
6a-h, 7a-h, 8a-g, 9a-g, 10a-e) were synthesized and evaluated the cytotoxicity. BAPs 6d, 7h …

Dissymmetric pyridyl-substituted 3, 5-bis (arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation

BR Yao, Y Sun, SL Chen, HD Suo, YL Zhang… - European Journal of …, 2019 - Elsevier
To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of
dissymmetric pyridyl-substituted 3, 5-bis (arylidene)-4-piperidones (BAPs, 25–82) were …

N-phenylsulfonyl-3, 5-bis (arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines

N Li, WY **n, BR Yao, W Cong, CH Wang… - European journal of …, 2018 - Elsevier
Abstract Ten novel symmetric 3, 5-bis (arylidene)-4-piperidone derivatives (BAPs, 1–10) and
fourteen dissymmetric BAPs (11–24) were synthesized and evaluated the cytotoxicity. All of …

Perspectives for synthetic curcumins in chemoprevention and treatment of cancer: An update with promising analogues

A Adeluola, AHM Zulfiker, D Brazeau… - European journal of …, 2021 - Elsevier
Curcumin, a pure compound extracted from the flowering plant, turmeric (Curcuma longa.
Zingiberaceae), is a common dietary ingredient found in curry powder. It has been studied …

Oridonin inhibits mTOR signaling and the growth of lung cancer tumors

YY Wang, YF Lv, L Lu, L Cai - Anti-Cancer Drugs, 2014 - journals.lww.com
Oridonin, an active diterpenoid isolated from Rabdosia rubescens, has been widely used for
treatment of various types of cancer. It has been shown that oridonin produced an …

[HTML][HTML] CLEFMA Induces the apoptosis of oral squamous carcinoma cells through the regulation of the P38/HO-1 signalling pathway

PN Chen, CW Lin, SF Yang, YC Chang - Cancers, 2022 - mdpi.com
Simple Summary Oral squamous cell carcinoma (OSCC) constitutes more than 90% of head
and neck cancers and a high prevalence rate in some parts of the world. Alcohol …