Prion protein (PrPc) was originally viewed solely as being involved in prion disease, but now
several intriguing lines of evidence have emerged indicating that it plays a fundamental role …

Simple Summary Aside from its well-established role in prion disorders, in the last decades
the significance of cellular prion protein (PrPC) expression in human cancers has attracted …

Cells from glioblastoma multiforme (GBM) feature up-regulation of the mechanistic Target of
Rapamycin (mTOR), which brings deleterious effects on malignancy and disease course. At …

Celiac disease (CD) is a severe genetic autoimmune disorder, affecting about one in 100
people, where the ingestion of gluten leads to damage in the small intestine. Diagnosing CD …

The cellular prion protein (PrPc) is an evolutionarily conserved cell surface protein encoded
by the PRNP gene. PrPc is ubiquitously expressed within nearly all mammalian cells …

An almost unique place within protein databases, twenty-five years of study has
underscored the enigmatically subtle role of PrP C in normal cell biology. It seems that PrP …

Thyroid cancer (THCA) is a common endocrine malignancy. With increasing incidence and
low mortality, balancing the therapeutic approach is an inevitable issue. This study aimed to …

Cellular prion protein (PrPC) is a membrane-anchored glycoprotein representing the
physiological counterpart of PrP scrapie (PrPSc), which plays a pathogenetic role in prion …

The carcinogenesis of glial tumors appears complex because of the many genetic and
epigenetic phenomena involved. Among these, cellular prion protein (PrPC) is considered a …

Doppel, a prion‐like protein, is a GPI‐membrane anchored protein generally not expressed
in the Central Nervous System (CNS) of different mammalian species, including human …