Genetics of common cerebral small vessel disease
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …
Ischemic stroke genetics: what is new and how to apply it in clinical practice?
A Ekkert, A Šliachtenko, J Grigaitė, B Burnytė, A Utkus… - Genes, 2021 - mdpi.com
The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic
causes make a significant contribution to ischemic stroke genesis, especially in early-onset …
causes make a significant contribution to ischemic stroke genesis, especially in early-onset …
Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …
however, whether they share pathophysiology is unclear and is the focus of our …
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …
ESO Guideline on covert cerebral small vessel disease
JM Wardlaw, S Debette, H Jokinen… - European Stroke …, 2021 - journals.sagepub.com
'Covert'cerebral small vessel disease (ccSVD) is common on neuroimaging in persons
without overt neurological manifestations, and increases the risk of future stroke, cognitive …
without overt neurological manifestations, and increases the risk of future stroke, cognitive …
Association of inflammatory markers with cerebral small vessel disease in community-based population
L Jiang, X Cai, D Yao, J **g, L Mei, Y Yang… - Journal of …, 2022 - Springer
Background This study investigated the relationships of neutrophil count (NC), neutrophil-to-
lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small …
lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small …
Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
M Siedlinski, L Carnevale, X Xu… - European heart …, 2023 - academic.oup.com
Background and aims Observational studies have linked elevated blood pressure (BP) to
impaired cognitive function. However, the functional and structural changes in the brain that …
impaired cognitive function. However, the functional and structural changes in the brain that …
Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities
Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections,
as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide …
as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide …