Beta-blockers: historical perspective and mechanisms of action
Beta-blockers are widely used molecules that are able to antagonize β-adrenergic receptors
(ARs), which belong to the G protein-coupled receptor family and receive their stimulus from …
(ARs), which belong to the G protein-coupled receptor family and receive their stimulus from …
Cardiovascular side-effects of antipsychotic drugs: the role of the autonomic nervous system
JYT Leung, AM Barr, RM Procyshyn, WG Honer… - Pharmacology & …, 2012 - Elsevier
Cardiovascular disease is the leading cause of death in people with severe mental
disorders, and rates are proportionally greater than for other diseases such as cancer …
disorders, and rates are proportionally greater than for other diseases such as cancer …
Functional Effects of KCNE3 Mutation and Its Role in the Development of Brugada Syndrome
Background—The Brugada syndrome, an inherited syndrome associated with a high
incidence of sudden cardiac arrest, has been linked to mutations in 4 different genes …
incidence of sudden cardiac arrest, has been linked to mutations in 4 different genes …
14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer
Y Zhang, M Yan, Y Yu, J Wang, Y Jiao, M Zheng… - Cell Communication and …, 2024 - Springer
Over the past decade, the role of the 14–3-3 protein has received increasing interest. Seven
subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its …
subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its …
Kir2. 1-Nav1. 5 channel complexes are differently regulated than Kir2. 1 and Nav1. 5 channels alone
RG Utrilla, P Nieto-Marín, S Alfayate… - Frontiers in …, 2017 - frontiersin.org
Cardiac Kir2. 1 and Nav1. 5 channels generate the inward rectifier K+ (IK1) and the Na+
(INa) currents, respectively. There is a mutual interplay between the ventricular INa and IK1 …
(INa) currents, respectively. There is a mutual interplay between the ventricular INa and IK1 …
Nitric Oxide Increases Cardiac IK1 by Nitrosylation of Cysteine 76 of Kir2.1 Channels
Rationale: The cardiac inwardly rectifying K+ current (I K1) plays a critical role in modulating
excitability by setting the resting membrane potential and sha** phase 3 of the cardiac …
excitability by setting the resting membrane potential and sha** phase 3 of the cardiac …
14–3-3 protein regulation of excitation–contraction coupling
WC Thompson, PH Goldspink - Pflügers Archiv-European Journal of …, 2022 - Springer
3-3 proteins (14–3-3 s) are a family of highly conserved proteins that regulate many cellular
processes in eukaryotes by interacting with a diverse array of client proteins. The 14–3-3 …
processes in eukaryotes by interacting with a diverse array of client proteins. The 14–3-3 …
Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs
T Rankinen, YJ Sung, MA Sarzynski… - Journal of Applied …, 2012 - journals.physiology.org
Endurance training-induced changes in hemodynamic traits are heritable. However, few
genes associated with heart rate training responses have been identified. The purpose of …
genes associated with heart rate training responses have been identified. The purpose of …
Protein-protein interactions at the adrenergic receptors
S Cotecchia, L Stanasila, D Diviani - Current drug targets, 2012 - ingentaconnect.com
The adrenergic receptors are among the best characterized G protein-coupled receptors
(GPCRs) and knowledge on this receptor family has provided several important paradigms …
(GPCRs) and knowledge on this receptor family has provided several important paradigms …
[HTML][HTML] Regulation of cardiac excitation and contraction by p21 activated kinase-1
Cardiac excitation and contraction are regulated by a variety of signaling molecules. Central
to the regulatory scheme are protein kinases and phosphatases that carry out reversible …
to the regulatory scheme are protein kinases and phosphatases that carry out reversible …