Protein secretion systems are vital for prokaryotic life, as they enable bacteria to acquire
nutrients, communicate with other species, defend against biological and chemical agents …

Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in
periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within …

Porphyromonas gingivalis, a gram-negative anaerobe, is a major etiological agent in the
initiation and progression of severe forms of periodontal disease. An opportunistic pathogen …

The large family of peptide-bond-cleaving hydrolases, the peptidases () proteases, EC 3.4),
can be categorized as endopeptidases () proteinases, EC 3.4. 21-99) and exopeptidases …

While classical studies on host-parasite interactions have considered a “virulence factor” to
be a molecule (s) that exerts a detrimental effect (that is, toxin) on a host cell, recent …

Gingipains are trypsin‐like cysteine proteinases produced by Porphyromonas gingivalis, a
major causative bacterium of adult periodontitis. HRgpA (95 kDa) and RgpB (50 kDa) …

Discusses the role of bacterial proteinases in matrix destruction and modulation of host
responses. Evasion of host defense mechanisms; Mechanism of gingipain inference with …

Gingipains, extracellular cysteine proteinases of Porphyromonas gingivalis, constitute the
major virulence factor of this periodontopathogenic bacterium. They are the product of three …

Porphyromonas gingivalis produces arginine-specific cysteine proteinase (Arg-gingipain,
RGP) and lysine-specific cysteine proteinase (Lys-gingipain, KGP) in the extracellular and …

Porphyromonas gingivalis is a Gram-negative anaerobic bacterium associated with the
initiation and progression of adult periodontal disease. Iron is utilized by this pathogen in the …