Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Presenilins were first discovered as sites of missense mutations responsible for early-onset
Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently …

Notch has been implicated in human cancers and is a putative therapeutic target. However,
the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore …

Breast cancer remains to be a dreadful disease even with several advancements in
radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by …

Triple‐negative breast cancer (TNBC) is a subgroup of 15%‐20% of diagnosed breast
cancer patients. It is generally considered to be the most difficult breast cancer subtype to …

High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no
data are available on the relationship between IL-6 and mammary stem/progenitor cells …

Most epithelial tissues self-renew throughout adult life due to the presence of multipotent
stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …