High-resolution mass spectrometry for human exposomics: Expanding chemical space coverage

Y Lai, JP Koelmel, DI Walker, EJ Price… - Environmental …, 2024 - ACS Publications
In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

Exploring the Chemical space of the exposome: how far have we gone?

S Samanipour, LP Barron, D van Herwerden… - JACS Au, 2024 - ACS Publications
Around two-thirds of chronic human disease can not be explained by genetics alone. The
Lancet Commission on Pollution and Health estimates that 16% of global premature deaths …

Combining nontargeted analysis with computer-based hazard comparison approaches to support prioritization of unregulated organic contaminants in biosolids

MN Newmeyer, Q Lyu, JR Sobus… - Environmental …, 2024 - ACS Publications
Biosolids are a byproduct of wastewater treatment that can be beneficially applied to
agricultural land as a fertilizer. While US regulations limit metals and pathogens in biosolids …

Bridging knowledge gaps in human chemical exposure via drinking water with non-target screening

D Ciccarelli, S Samanipour, H Rapp-Wright… - Critical Reviews in …, 2025 - Taylor & Francis
Fundamental knowledge gaps still exist in the exposome, especially regarding analytical
space coverage, map** and prioritization of a very large number of diverse chemical …

[HTML][HTML] Pioneering an effect-based early warning system for hazardous chemicals in the environment

G Niarchos, N Alygizakis, M Carere, V Dulio… - TrAC Trends in …, 2024 - Elsevier
Existing regulatory frameworks often prove inadequate in promptly identifying contaminants
of emerging concern (CECs) and determining their impacts on biological systems at an early …

Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison

L Malm, J Liigand, R Aalizadeh, N Alygizakis… - Analytical …, 2024 - ACS Publications
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-
resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental …

Tracing contaminants of emerging concern and their transformations in the whole treatment process of a municipal wastewater treatment plant using nontarget …

Z Chen, D **a, H Liu, R Wang, M Huang, T Tang, G Lu - Water Research, 2024 - Elsevier
This study employed nontarget screening with high-resolution mass spectrometry and
molecular network strategy to characterize the occurrence and tranformation of …

[HTML][HTML] Unveiling industrial emissions in a large European river: Insights from data mining of high-frequency measurements

T Chonova, S Ruppe, I Langlois, DS Griesshaber… - Water Research, 2025 - Elsevier
Despite the tremendous efforts to improve river water quality, chemical contamination
remains a significant issue. Besides well-known contaminants, in recent years, pollutants of …

Occurrence of contaminants of emerging concern in different water samples from the lower part of the Danube River Middle Basin–A review

N Đurišić-Mladenović, J Živančev, I Antić, D Rakić… - Environmental …, 2024 - Elsevier
This study intends to assess the extent of the occurrence of CECs in different water types
based on the literature data reported for the countries from a lower part of the Middle …

Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification—is it time for HT-EDA?

I Alvarez-Mora, K Arturi, F Béen, S Buchinger… - Analytical and …, 2025 - Springer
The rapid increase in the production and global use of chemicals and their mixtures has
raised concerns about their potential impact on human and environmental health. With …