High-resolution mass spectrometry for human exposomics: Expanding chemical space coverage

Y Lai, JP Koelmel, DI Walker, EJ Price… - Environmental …, 2024 - ACS Publications
In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening …

S Lennon, J Chaker, EJ Price, J Hollender… - TrAC Trends in …, 2024 - Elsevier
Non-targeted and suspect screening analysis using liquid chromatography coupled to high-
resolution mass spectrometry (LC-HRMS) holds great promise to comprehensively …

Combining nontargeted analysis with computer-based hazard comparison approaches to support prioritization of unregulated organic contaminants in biosolids

MN Newmeyer, Q Lyu, JR Sobus… - Environmental …, 2024 - ACS Publications
Biosolids are a byproduct of wastewater treatment that can be beneficially applied to
agricultural land as a fertilizer. While US regulations limit metals and pathogens in biosolids …

Online and Offline Prioritization of Chemicals of Interest in Suspect Screening and Non-targeted Screening with High-Resolution Mass Spectrometry

D Szabo, TM Falconer, CM Fisher, T Heise… - Analytical …, 2024 - ACS Publications
Recent advances in high-resolution mass spectrometry (HRMS) have enabled the detection
of thousands of chemicals from a single sample, while computational methods have …

Exploring the Chemical space of the exposome: how far have we gone?

S Samanipour, LP Barron, D van Herwerden… - JACS Au, 2024 - ACS Publications
Around two-thirds of chronic human disease can not be explained by genetics alone. The
Lancet Commission on Pollution and Health estimates that 16% of global premature deaths …

Bridging knowledge gaps in human chemical exposure via drinking water with non-target screening

D Ciccarelli, S Samanipour, H Rapp-Wright… - Critical Reviews in …, 2025 - Taylor & Francis
Fundamental knowledge gaps still exist in the exposome, especially regarding analytical
space coverage, map** and prioritization of a very large number of diverse chemical …

[HTML][HTML] Pioneering an effect-based early warning system for hazardous chemicals in the environment

G Niarchos, N Alygizakis, M Carere, V Dulio… - TrAC Trends in …, 2024 - Elsevier
Existing regulatory frameworks often prove inadequate in promptly identifying contaminants
of emerging concern (CECs) and determining their impacts on biological systems at an early …

[HTML][HTML] Scientometric review: Concentration and toxicity assessment in environmental non-targeted LC/HRMS analysis

H Sepman, L Malm, P Peets, A Kruve - Trends in Environmental Analytical …, 2023 - Elsevier
Non-targeted screening with LC/HRMS is a go-to approach to discover relevant
contaminants in environmental water samples that contain an abundance of chemicals. The …

Quantitative nontarget analysis of CECs in environmental samples can be improved by considering all mass adducts

S Tisler, K Kilpinen, DI Pattison, G Tomasi… - Analytical …, 2023 - ACS Publications
Quantitative nontarget analysis (qNTA) for liquid chromatography coupled to high-resolution
mass spectrometry enables a more comprehensive assessment of environmental samples …

[HTML][HTML] Characterization of nutrients and contaminants in fish sludge from Atlantic salmon (Salmo salar L.) production sites-A future resource

V Sele, A Ali, N Liland, AK Lundebye, J Tibon… - Journal of …, 2024 - Elsevier
A total of 47 fish sludge samples from commercial land-based Atlantic salmon (Salmo salar)
farms in Norway were assessed for their nutrient composition, presence of various legacy …