The develo** brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

Epilepsy is characterized by spontaneous recurrent seizures and comprises a diverse group
of syndromes with different etiologies. Epileptogenesis refers to the process whereby the …

Birth is associated with a neuroprotective, oxytocin-mediated abrupt excitatory-to-inhibitory
GABA shift that is abolished in autism, and its restoration attenuates the disorder in offspring …

Newborn neurons in develo** brains actively migrate from germinal zones to designated
regions before being wired into functional circuits. The motility and trajectory of migrating …

A wide spectrum of focal, regional, or diffuse structural brain abnormalities, collectively
known as malformations of cortical development (MCDs), frequently manifest with …

The develo** immature brain is not simply a small adult brain but rather possesses unique
physiological properties. These include neuronal ionic currents that differ markedly from …

X-linked isolated lissencephaly sequence and subcortical band heterotopia are allelic
human disorders associated with mutations of doublecortin (DCX), giving both familial and …

Grey matter heterotopia (GMH) are neurodevelopmental disorders associated with abnormal
cortical function and epilepsy. Subcortical band heterotopia (SBH) and periventricular …

Intellectual disability is a prevalent disorder that remains incurable. Mutations of the X-linked
protein PHF6 cause the intellectual disability disorder Börjeson-Forssman-Lehmann …