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A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Structure and function of carbonic anhydrases
CT Supuran - Biochemical Journal, 2016 - portlandpress.com
Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse the interconversion between CO2 and
bicarbonate as well as other hydrolytic reactions. Among the six genetic families known to …
bicarbonate as well as other hydrolytic reactions. Among the six genetic families known to …
Advances in structure-based drug discovery of carbonic anhydrase inhibitors
CT Supuran - Expert opinion on drug discovery, 2017 - Taylor & Francis
Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …
Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery
C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2024 - Taylor & Francis
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
A Kumar, K Siwach, CT Supuran, PK Sharma - Bioorganic chemistry, 2022 - Elsevier
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery
CT Supuran - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
An overview on the recently discovered iota-carbonic anhydrases
A Nocentini, CT Supuran, C Capasso - Journal of Enzyme …, 2021 - Taylor & Francis
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) have been studied for decades and have
been classified as a superfamily of enzymes which includes, up to date, eight gene families …
been classified as a superfamily of enzymes which includes, up to date, eight gene families …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
A Nocentini, A Angeli, F Carta, JY Winum… - Journal of Enzyme …, 2021 - Taylor & Francis
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
The many types of carbonic anhydrases in photosynthetic organisms
RJ DiMario, MC Machingura, GL Waldrop, JV Moroney - Plant science, 2018 - Elsevier
Carbonic anhydrases (CAs) are enzymes that catalyze the interconversion of CO 2 and HCO
3−. In nature, there are multiple families of CA, designated with the Greek letters α through θ …
3−. In nature, there are multiple families of CA, designated with the Greek letters α through θ …
Energizing the CO2 utilization by chemo-enzymatic approaches and potentiality of carbonic anhydrases: A review
T Sharma, S Sharma, H Kamyab, A Kumar - Journal of Cleaner Production, 2020 - Elsevier
During the last few decades, enormous emissions of greenhouse gases (GHGs) into the
atmosphere by human activities, lead to global warming. Thus, it becomes essential to …
atmosphere by human activities, lead to global warming. Thus, it becomes essential to …