Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse the interconversion between CO2 and
bicarbonate as well as other hydrolytic reactions. Among the six genetic families known to …

Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …

Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …

Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) have been studied for decades and have
been classified as a superfamily of enzymes which includes, up to date, eight gene families …

Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …

Carbonic anhydrases (CAs) are enzymes that catalyze the interconversion of CO 2 and HCO
3−. In nature, there are multiple families of CA, designated with the Greek letters α through θ …

During the last few decades, enormous emissions of greenhouse gases (GHGs) into the
atmosphere by human activities, lead to global warming. Thus, it becomes essential to …