Targeting head and neck cancer stem cells to overcome resistance to photon and carbon ion radiation
G Bertrand, M Maalouf, A Boivin… - Stem Cell Reviews and …, 2014 - Springer
Although promising new radiation therapy techniques such as hadrontherapy are currently
being evaluated in the treatment of head and neck malignancies, local control of head and …
being evaluated in the treatment of head and neck malignancies, local control of head and …
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
J Hong, K Hu, Y Yuan, Y Sang, Q Bu… - The Journal of …, 2012 - Am Soc Clin Investig
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to
current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic …
current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic …
Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53
MA Gadhikar, MR Sciuto, MVO Alves… - Molecular cancer …, 2013 - AACR
Despite the use of multimodality therapy using cisplatin to treat patients with advanced stage
squamous cell carcinoma of the head and neck (HNSCC), there is an unacceptably high …
squamous cell carcinoma of the head and neck (HNSCC), there is an unacceptably high …
Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers
C Bryant, R Rawlinson, AJ Massey - BMC cancer, 2014 - Springer
Background Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic
chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers …
chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers …
Momordica Charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo
The incidence of nasopharyngeal carcinoma (NPC) remains high in endemic regions,
including southern China, northern Africa, and North America. One of the promising …
including southern China, northern Africa, and North America. One of the promising …
Disulfiram acts as a potent radio-chemo sensitizer in head and neck squamous cell carcinoma cell lines and transplanted xenografts
W Yao, X Qian, S Ochsenreither, F Soldano, AB DeLeo… - Cells, 2021 - mdpi.com
The poor prognosis of locally advanced and metastatic head and neck squamous cell
carcinoma (HNSCC) is primarily mediated by the functional properties of cancer stem cells …
carcinoma (HNSCC) is primarily mediated by the functional properties of cancer stem cells …
Suppression of Jab1/CSN5 induces radio-and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways
Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus-associated malignancy most
common in East Asia and Africa. Radiotherapy and cisplatin-based chemotherapy are the …
common in East Asia and Africa. Radiotherapy and cisplatin-based chemotherapy are the …
DNA damage checkpoints in nasopharyngeal carcinoma
RYC Poon - Oral Oncology, 2014 - Elsevier
Nasopharyngeal carcinoma (NPC) is a highly invasive cancer with poor prognosis. One of
the recurring themes of NPC biology and treatments is DNA damage. Epstein–Barr virus …
the recurring themes of NPC biology and treatments is DNA damage. Epstein–Barr virus …
Targeted radiosensitization by the Chk1 inhibitor SAR-020106
GR Borst, M McLaughlin, JN Kyula, S Neijenhuis… - International Journal of …, 2013 - Elsevier
PURPOSE: To explore the activity of a potent Chk1 inhibitor (SAR-020106) in combination
with radiation. METHODS AND MATERIALS: Colony and mechanistic in vitro assays and a …
with radiation. METHODS AND MATERIALS: Colony and mechanistic in vitro assays and a …
Nimotuzumab promotes radiosensitivity of EGFR-overexpression esophageal squamous cell carcinoma cells by upregulating IGFBP-3
L Zhao, LR He, M **, MY Cai, JX Shen, QQ Li… - Journal of translational …, 2012 - Springer
Background Epidermal growth factor receptor (EGFR) is suggested to predict the
radiosensitivity and/or prognosis of human esophageal squamous cell carcinoma (ESCC) …
radiosensitivity and/or prognosis of human esophageal squamous cell carcinoma (ESCC) …