Lactoferrin's anti-cancer properties: Safety, selectivity, and wide range of action

A Cutone, L Rosa, G Ianiro, MS Lepanto… - Biomolecules, 2020 - mdpi.com
Despite recent advances in cancer therapy, current treatments, including radiotherapy,
chemotherapy, and immunotherapy, although beneficial, present attendant side effects and …

[HTML][HTML] Current research status of anti-cancer peptides: Mechanism of action, production, and clinical applications

RK Chinnadurai, N Khan, GK Meghwanshi… - Biomedicine & …, 2023 - Elsevier
The escalating rate of cancer cases, together with treatment deficiencies and long-term side
effects of currently used cancer drugs, has made this disease a global burden of the 21st …

Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects

AA Baxter, FT Lay, IKH Poon, M Kvansakul… - Cellular and Molecular …, 2017 - Springer
There is an ongoing need for effective and targeted cancer treatments that can overcome the
detrimental side effects presented by current treatment options. One class of novel …

Anticancer potential of bioactive peptides from animal sources

L Wang, C Dong, X Li, W Han, X Su - Oncology reports, 2017 - spandidos-publications.com
Cancer is the most common cause of human death worldwide. Conventional anticancer
therapies, including chemotherapy and radiation, are associated with severe side effects …

Time to kill and time to heal: the multifaceted role of lactoferrin and lactoferricin in host defense

A Ohradanova-Repic, R Praženicová, L Gebetsberger… - Pharmaceutics, 2023 - mdpi.com
Lactoferrin is an iron-binding glycoprotein present in most human exocrine fluids,
particularly breast milk. Lactoferrin is also released from neutrophil granules, and its …

Targeting cancer heterogeneity with immune responses driven by oncolytic peptides

I Vitale, T Yamazaki, E Wennerberg, B Sveinbjørnsson… - Trends in Cancer, 2021 - cell.com
Accumulating preclinical and clinical evidence indicates that high degrees of heterogeneity
among malignant cells constitute a considerable obstacle to the success of cancer therapy …

Natural peptides inducing cancer cell death: Mechanisms and properties of specific candidates for cancer therapeutics

PA Trinidad-Calderón, CD Varela-Chinchilla… - Molecules, 2021 - mdpi.com
Nowadays, cancer has become the second highest leading cause of death, and it is
expected to continue to affect the population in forthcoming years. Additionally, treatment …

Techniques, perspectives, and challenges of bioactive peptide generation: A comprehensive systematic review

M Barati, F Javanmardi… - … Reviews in Food …, 2020 - Wiley Online Library
Due to the digestible refractory and absorbable structures of bioactive peptides (BPs), they
could induce notable biological impacts on the living organism. In this regard, the current …

Discovery of a 9-mer cationic peptide (LTX-315) as a potential first in class oncolytic peptide

BE Haug, KA Camilio, LT Eliassen, W Stensen… - 2016 - ACS Publications
Oncolytic immunotherapies represent a new promising strategy in the treatment of cancer. In
our efforts to develop oncolytic peptides, we identified a series of chemically modified 9-mer …

Anticancer activities of bovine and human lactoferricin-derived peptides

M Arias, AL Hilchie, EF Haney… - … and Cell biology, 2017 - cdnsciencepub.com
Lactoferrin (LF) is a mammalian host defense glycoprotein with diverse biological activities.
Peptides derived from the cationic region of LF possess cytotoxic activity against cancer …