Immunogenicity of extracellular vesicles
Extracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery
systems due to demonstrated safety and efficacy in preclinical models and early‐stage …
systems due to demonstrated safety and efficacy in preclinical models and early‐stage …
[HTML][HTML] Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective
Chronic non-healing wounds persist as a substantial burden for healthcare systems,
influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro …
influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro …
Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based epigenome editing in Alzheimer's disease
Effective intracellular delivery of therapeutic proteins can potentially treat a wide array of
diseases. However, efficient delivery of functional proteins across the cell membrane …
diseases. However, efficient delivery of functional proteins across the cell membrane …
[HTML][HTML] A comprehensive review on recent advances in exosome isolation and characterization: Toward clinical applications
N Dilsiz - Translational Oncology, 2024 - Elsevier
Exosomes are small, round vesicles in the 30 and 120 nm diameter range released by all
living cell types. Exosomes play many essential functions in intercellular communication and …
living cell types. Exosomes play many essential functions in intercellular communication and …
A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy
M Van Delen, J Derdelinckx, K Wouters… - Journal of …, 2024 - Wiley Online Library
Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste
disposal vesicle but are an essential part of an intercellular communication system. Besides …
disposal vesicle but are an essential part of an intercellular communication system. Besides …
Engineering therapeutical extracellular vesicles for clinical translation
Cell-based therapies are revolutionizing medicine by replacing or modifying dysfunctional
cells with healthy cells or engineered derivatives, offering disease reversal and cure. One …
cells with healthy cells or engineered derivatives, offering disease reversal and cure. One …
[HTML][HTML] Mesenchymal stem cell-derived exosomes as drug delivery vehicles in disease therapy
W Zhao, K Li, L Li, R Wang, Y Lei, H Yang… - International Journal of …, 2024 - mdpi.com
Exosomes are small vesicles containing proteins, nucleic acids, and biological lipids, which
are responsible for intercellular communication. Studies have shown that exosomes can be …
are responsible for intercellular communication. Studies have shown that exosomes can be …
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple
neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates …
neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates …
A critical systematic review of extracellular vesicle clinical trials
This systematic review examines the landscape of extracellular vesicle (EV)‐related clinical
trials to elucidate the field's trends in clinical applications and EV‐related methodologies …
trials to elucidate the field's trends in clinical applications and EV‐related methodologies …
Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications
Extracellular vesicles (EVs) are diverse nanoparticles with large heterogeneity in size and
molecular composition. Although this heterogeneity provides high diagnostic value for liquid …
molecular composition. Although this heterogeneity provides high diagnostic value for liquid …