HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment

D Saylor, AM Dickens, N Sacktor, N Haughey… - Nature Reviews …, 2016 - nature.com
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

Cognitive disorders in people living with HIV

A Winston, S Spudich - The Lancet HIV, 2020 - thelancet.com
High rates of cognitive disorders in antiretroviral-treated people living with HIV have been
described worldwide. The exact prevalence of such cognitive disorders is determined by the …

[HTML][HTML] Cerebral micro-structural changes in COVID-19 patients–an MRI-based 3-month follow-up study

Y Lu, X Li, D Geng, N Mei, PY Wu, CC Huang… - …, 2020 - thelancet.com
Background Increasing evidence supported the possible neuro-invasion potential of SARS-
CoV-2. However, no studies were conducted to explore the existence of the micro-structural …

Macrophages but not astrocytes harbor HIV DNA in the brains of HIV-1-infected aviremic individuals on suppressive antiretroviral therapy

A Ko, G Kang, JB Hattler, HI Galadima, J Zhang… - Journal of Neuroimmune …, 2019 - Springer
The question of whether the human brain is an anatomical site of persistent HIV-1 infection
during suppressive antiretroviral therapy (ART) is critical, but remains unanswered. The …

Blood biomarkers for detection of brain injury in COVID-19 patients

ST DeKosky, PM Kochanek, AB Valadka… - Journal of …, 2021 - liebertpub.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple
organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are …

Association of brain structure changes and cognitive function with combination antiretroviral therapy in HIV-positive individuals

R Sanford, LK Fellows, BM Ances, DL Collins - JAMA neurology, 2018 - jamanetwork.com
Importance Despite the introduction of combination antiretroviral therapy (cART), HIV-
associated neurocognitive disorders continue to be a problem for treated HIV-positive …

Global HIV neurology: a comprehensive review

KT Thakur, A Boubour, D Saylor, M Das, DR Bearden… - Aids, 2019 - journals.lww.com
Neurological conditions associated with HIV remain major contributors to morbidity and
mortality and are increasingly recognized in the aging population on long-standing …

HIV in the brain: identifying viral reservoirs and addressing the challenges of an HIV cure

MK Ash, L Al-Harthi, JR Schneider - Vaccines, 2021 - mdpi.com
Advances in antiretroviral therapy have prolonged the life of people living with HIV and
diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption …

[HTML][HTML] HIV-associated neurocognitive disorders: recent advances in pathogenesis, biomarkers, and treatment

A Carroll, B Brew - F1000Research, 2017 - ncbi.nlm.nih.gov
HIV-associated neurocognitive disorders (HAND) remain prevalent despite plasma viral
suppression by antiretroviral agents. In fact, the prevalence of milder subtypes of cognitive …

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging

AM Dickens, SW Yoo, AC Chin, J Xu, TP Johnson… - Scientific reports, 2017 - nature.com
The widespread use of combinational antiretroviral therapies (cART) in developed countries
has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost …