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Lights, fiber, action! A primer on in vivo fiber photometry
Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …
Astrocytes: new evidence, new models, new roles
Astrocytes have been in the limelight of active research for about 3 decades now. Over this
period, ideas about their function and role in the nervous system have evolved from simple …
period, ideas about their function and role in the nervous system have evolved from simple …
Adenosine signalling to astrocytes coordinates brain metabolism and function
Brain computation performed by billions of nerve cells relies on a sufficient and
uninterrupted nutrient and oxygen supply,. Astrocytes, the ubiquitous glial neighbours of …
uninterrupted nutrient and oxygen supply,. Astrocytes, the ubiquitous glial neighbours of …
40 Hz light flickering promotes sleep through cortical adenosine signaling
Flickering light stimulation has emerged as a promising non-invasive neuromodulation
strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical …
strategy to alleviate neuropsychiatric disorders. However, the lack of a neurochemical …
40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice
X Sun, L Dias, C Peng, Z Zhang, H Ge, Z Wang, J **… - Cell Discovery, 2024 - nature.com
The glymphatic-lymphatic system is increasingly recognized as fundamental for the
homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain …
homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain …
Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors
K Roy, X Zhou, R Otani, PC Yuan, S Ioka… - Nature …, 2024 - nature.com
Optochemistry, an emerging pharmacologic approach in which light is used to selectively
activate or deactivate molecules, has the potential to alleviate symptoms, cure diseases, and …
activate or deactivate molecules, has the potential to alleviate symptoms, cure diseases, and …
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation
Neuronal activity creates an intense energy demand that must be met by rapid metabolic
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …
Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis
Astrocytes regulate brain functions through gliotransmitters like ATP/ADP and glutamate, but
their release patterns and mechanisms remain controversial. Here, we visualized ATP/ADP …
their release patterns and mechanisms remain controversial. Here, we visualized ATP/ADP …
Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Abstract Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide
with key regulatory functions in several central behavioral processes including motivation …
with key regulatory functions in several central behavioral processes including motivation …
A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release
X **a, Y Li - Nature communications, 2025 - nature.com
The co-existence and co-transmission of neuropeptides and small molecule
neurotransmitters within individual neuron represent a fundamental characteristic observed …
neurotransmitters within individual neuron represent a fundamental characteristic observed …