Current HLA investigations on SARS-CoV-2 and perspectives

V Douillard, EC Castelli, SJ Mack, JA Hollenbach… - Frontiers in …, 2021 - frontiersin.org
The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has
triggered numerous efforts in clinical and research settings to better understand the host …

Genome-wide association study of bladder cancer reveals new biological and translational insights

S Koutros, LA Kiemeney, PP Choudhury, RL Milne… - European urology, 2023 - Elsevier
Background Genomic regions identified by genome-wide association studies (GWAS) for
bladder cancer risk provide new insights into etiology. Objective To identify new …

Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation

X Guo, P Tang, X Zhang, R Li - Inflammation Research, 2023 - Springer
Background Observational studies have shown that Helicobacter pylori (H. pylori) infection
and H. pylori antibodies are associated with an increased risk of stroke. However, which and …

HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases

G Butler-Laporte, J Farjoun, T Nakanishi, T Lu… - Communications …, 2023 - nature.com
The human leukocyte antigen (HLA) region on chromosome 6 is strongly associated with
many immune-mediated and infection-related diseases. Due to its highly polymorphic nature …

Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis

S Zhong, W Yang, Z Zhang, Y **e, L Pan, J Ren, F Ren… - BMC medicine, 2023 - Springer
Background Glioma is one of the leading types of brain tumor, but few etiologic factors of
primary glioma have been identified. Previous observational research has shown an …

Use of bidirectional Mendelian randomization to unveil the association of Helicobacter pylori infection and autoimmune thyroid diseases

K Wang, Q Zhang, P Zhang, Q Yang, F Pan, B Zha - Science Advances, 2024 - science.org
Previous observational studies found associations between Helicobacter pylori infection and
autoimmune thyroid diseases (AITDs), but the causal nature of this association is still …

Appraising the life‐course impact of Epstein‐Barr virus exposure and its genetic signature on periodontitis

X Ye, J Yuan, Y Bai, Y Chen, H Jiang… - Journal of …, 2024 - Wiley Online Library
Background Periodontitis arises from a multifaceted interplay of environmental variables and
genetic susceptibility, where microbial infection plays an indispensable part. Epstein‐Barr …

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

AY Chong, N Brenner, A Jimenez-Kaufmann… - The American Journal of …, 2024 - cell.com
Infectious agents contribute significantly to the global burden of diseases through both acute
infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci …

Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization

X Zhang, Y Shi, T Li, K Chang, Y Gan, Y Feng… - BMC Cardiovascular …, 2024 - Springer
Background Helicobacter pylori (H. pylori), according to a number of recent observational
studies, is connected to atherosclerosis (AS). However, the link between H. pylori and AS is …

Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer

Y Yang, J Chen, F Gong, J Miao, M Lin, R Liu… - Scientific Reports, 2024 - nature.com
Background: There may be potential associations between various pathogens, antibody
immune responses, and breast cancer (BC), but the specific mechanisms and causal …