Current HLA investigations on SARS-CoV-2 and perspectives
The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has
triggered numerous efforts in clinical and research settings to better understand the host …
triggered numerous efforts in clinical and research settings to better understand the host …
Genome-wide association study of bladder cancer reveals new biological and translational insights
Background Genomic regions identified by genome-wide association studies (GWAS) for
bladder cancer risk provide new insights into etiology. Objective To identify new …
bladder cancer risk provide new insights into etiology. Objective To identify new …
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation
Background Observational studies have shown that Helicobacter pylori (H. pylori) infection
and H. pylori antibodies are associated with an increased risk of stroke. However, which and …
and H. pylori antibodies are associated with an increased risk of stroke. However, which and …
HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases
The human leukocyte antigen (HLA) region on chromosome 6 is strongly associated with
many immune-mediated and infection-related diseases. Due to its highly polymorphic nature …
many immune-mediated and infection-related diseases. Due to its highly polymorphic nature …
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis
Background Glioma is one of the leading types of brain tumor, but few etiologic factors of
primary glioma have been identified. Previous observational research has shown an …
primary glioma have been identified. Previous observational research has shown an …
Use of bidirectional Mendelian randomization to unveil the association of Helicobacter pylori infection and autoimmune thyroid diseases
K Wang, Q Zhang, P Zhang, Q Yang, F Pan, B Zha - Science Advances, 2024 - science.org
Previous observational studies found associations between Helicobacter pylori infection and
autoimmune thyroid diseases (AITDs), but the causal nature of this association is still …
autoimmune thyroid diseases (AITDs), but the causal nature of this association is still …
Appraising the life‐course impact of Epstein‐Barr virus exposure and its genetic signature on periodontitis
X Ye, J Yuan, Y Bai, Y Chen, H Jiang… - Journal of …, 2024 - Wiley Online Library
Background Periodontitis arises from a multifaceted interplay of environmental variables and
genetic susceptibility, where microbial infection plays an indispensable part. Epstein‐Barr …
genetic susceptibility, where microbial infection plays an indispensable part. Epstein‐Barr …
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
AY Chong, N Brenner, A Jimenez-Kaufmann… - The American Journal of …, 2024 - cell.com
Infectious agents contribute significantly to the global burden of diseases through both acute
infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci …
infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci …
Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization
X Zhang, Y Shi, T Li, K Chang, Y Gan, Y Feng… - BMC Cardiovascular …, 2024 - Springer
Background Helicobacter pylori (H. pylori), according to a number of recent observational
studies, is connected to atherosclerosis (AS). However, the link between H. pylori and AS is …
studies, is connected to atherosclerosis (AS). However, the link between H. pylori and AS is …
Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer
Y Yang, J Chen, F Gong, J Miao, M Lin, R Liu… - Scientific Reports, 2024 - nature.com
Background: There may be potential associations between various pathogens, antibody
immune responses, and breast cancer (BC), but the specific mechanisms and causal …
immune responses, and breast cancer (BC), but the specific mechanisms and causal …